A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β-catenin stabilization-induced EMT
AR Kang, JL Kim, YH Kim, S Kang, SC Oh… - Cancer Gene …, 2023 - nature.com
RIP1 (receptor-interacting protein kinase 1) is an important component of TNF-α signaling
that contributes to various pathological effects. Here, we revealed new potential roles of …
that contributes to various pathological effects. Here, we revealed new potential roles of …
The mechanism of branched-chain amino acid transferases in different diseases: Research progress and future prospects
X Nong, C Zhang, J Wang, P Ding, G Ji, T Wu - Frontiers in Oncology, 2022 - frontiersin.org
It is well known that the enzyme catalyzes the first step of branched-chain amino acid
(BCAA) catabolism is branched-chain amino transferase (BCAT), which is involved in the …
(BCAA) catabolism is branched-chain amino transferase (BCAT), which is involved in the …
Identifying biomarkers associated with immunotherapy response in melanoma by multi-omics analysis
Y He, X Wang - Computers in Biology and Medicine, 2023 - Elsevier
Despite immune checkpoint inhibitors (ICIs) have shown the greatest success in melanoma
treatment, only a subset of melanoma patients responds well to ICIs. Thus, identifying …
treatment, only a subset of melanoma patients responds well to ICIs. Thus, identifying …
An optimal Bayesian intervention policy in response to unknown dynamic cell stimuli
SH Hosseini, M Imani - Information Sciences, 2024 - Elsevier
Interventions in gene regulatory networks (GRNs) aim to restore normal functions of cells
experiencing abnormal behavior, such as uncontrolled cell proliferation. The dynamic …
experiencing abnormal behavior, such as uncontrolled cell proliferation. The dynamic …
Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy
X Lu, X Chen, C Lin, Y Yi, S Zhao, B Zhu… - Advanced …, 2024 - Wiley Online Library
The induction of cuproptosis, a recently identified form of copper‐dependent immunogenic
cell death, is a promising approach for antitumor therapy. However, sufficient accumulation …
cell death, is a promising approach for antitumor therapy. However, sufficient accumulation …
Comprehensive characterisation of immunogenic cell death in melanoma revealing the association with prognosis and tumor immune microenvironment
J Ren, J Yang, S Na, Y Wang, L Zhang… - Frontiers in …, 2022 - frontiersin.org
Increasing evidence has highlighted the critical functions of immunogenic cell death (ICD)
within many tumors. However, the therapeutic possibilities and mechanism of utilizing ICD in …
within many tumors. However, the therapeutic possibilities and mechanism of utilizing ICD in …
Autophagy in BRAF-mutant cutaneous melanoma: recent advances and therapeutic perspective
E Fratta, G Giurato, R Guerrieri, F Colizzi… - Cell Death …, 2023 - nature.com
Macroautophagy, hereafter referred to as autophagy, represents a highly conserved
catabolic process that maintains cellular homeostasis. At present, the role of autophagy in …
catabolic process that maintains cellular homeostasis. At present, the role of autophagy in …
Dihydroartemisinin inhibits melanoma migration and metastasis by affecting angiogenesis
Z Li, Q Zhang, X Zhang, Q Jin, Q Yue, N Li… - Phytotherapy …, 2023 - Wiley Online Library
Tumor angiogenesis is critical for tumor metastasis by providing oxygen, nutrients, and
metastatic pathways. As a potential anti‐angiogenic agent, Dihydroartemisinin (DHA) can …
metastatic pathways. As a potential anti‐angiogenic agent, Dihydroartemisinin (DHA) can …
Current treatment of melanoma brain metastases
A Nowacka, A Fajkiel-Madajczyk, J Ohla… - Cancers, 2023 - mdpi.com
Simple Summary Melanoma has the highest mortality rate of all skin cancers and its
prognosis is worsened by metastasis to the brain. Before discovering new treatments for …
prognosis is worsened by metastasis to the brain. Before discovering new treatments for …
[HTML][HTML] Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes
Melanoma continues to be a leading cause of mortality among skin cancers. Despite
advancements in targeted therapy, patients frequently develop resistance, leading to …
advancements in targeted therapy, patients frequently develop resistance, leading to …