Oxidative-stress-sensitive microRNAs in UV-promoted development of melanoma

A Pecorelli, G Valacchi - Cancers, 2022 - mdpi.com
Simple Summary Exposure to ultraviolet (UV) rays from the sun is one of the most important
modifiable risk factors for skin cancer. Melanoma is the most life-threatening type of skin …

OTUD4 regulates metastasis and chemoresistance in melanoma by stabilizing Snail1

Y Gao, J Tang, X Ma, C Zhang, L Huang… - Journal of Cellular …, 2023 - Wiley Online Library
Melanoma is the most aggressive form of skin cancer with rapidly increased incidence
worldwide especially in the Caucasian population. Surgical excision represents the curative …

BCAT2 promotes melanoma progression by activating lipogenesis via the epigenetic regulation of FASN and ACLY expressions

Y Tian, J Ma, H Wang, X Yi, H Wang, H Zhang… - Cellular and Molecular …, 2023 - Springer
Melanoma is the most lethal skin cancer originating from the malignant transformation of
epidermal melanocyte. The dysregulation of cellular metabolism is a hallmark of cancer …

Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the …

L Guo, Z Dong, X Zhang, Y Yang, X Hu, Y Ji, C Li… - Phytomedicine, 2023 - Elsevier
Backgroud Flavonoids have a variety of biological activities, such as anti-inflammation, anti-
tumor, anti-thrombosis and so on. Morusinol, as a novel isoprene flavonoid extracted from …

Epithelial-to-Mesenchymal Transition Gene Signature in Circulating Melanoma Cells: Biological and Clinical Relevance

MC Rapanotti, E Cugini, E Campione… - International Journal of …, 2023 - mdpi.com
The most promising method for monitoring patients with minimal morbidity is the detection of
circulating melanoma cells (CMCs). We have shown that CD45− CD146+ ABCB5+ CMCs …

[HTML][HTML] Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes

M Steinhoff, M Alam, A Ahmad, S Uddin… - Seminars in Cancer …, 2022 - Elsevier
The skin is the largest organ of the human body and prone to various diseases, including
cancer; thus, provides the first line of defense against exogenous biological and non …

STK19 is a DNA/RNA-binding protein critical for DNA damage repair and cell proliferation

Y Li, Y Gong, Y Zhou, Y Xiao, W Huang, Q Zhou… - Journal of Cell …, 2024 - rupress.org
STK19 was originally identified as a manganese-dependent serine/threonine-specific
protein kinase, but its function has been highly debated. Here, the crystal structure of STK19 …

From Vibrations to Visions: Raman Spectroscopy's Impact on Skin Cancer Diagnostics

C Delrue, R Speeckaert, M Oyaert… - Journal of Clinical …, 2023 - mdpi.com
Raman spectroscopy, a non-invasive diagnostic technique capturing molecular vibrations,
offers significant advancements in skin cancer diagnostics. This review delineates the …

Functionalization of Nanomaterials for Skin Cancer Theranostics

C Zhang, X Zhu, S Hou, W Pan, W Liao - Frontiers in Bioengineering …, 2022 - frontiersin.org
Skin cancer has drawn attention for the increasing incident rates and high morbidity
worldwide. Timely diagnosis and efficient treatment are of paramount importance for prompt …

[HTML][HTML] Tozasertib activates anti-tumor immunity through decreasing regulatory T cells in melanoma

Q Wang, W Liu, H Zhou, W Lai, C Hu, Y Dai, G Li… - Neoplasia, 2024 - Elsevier
Although immune checkpoint therapy has significantly improved the prognosis of patients
with melanoma, urgent attention still needs to be paid to the low patient response rates and …