[HTML][HTML] Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: pathogenic mechanisms and therapeutic potential
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
[HTML][HTML] AAV vectors applied to the treatment of CNS disorders: Clinical status and challenges
L Kang, S Jin, J Wang, Z Lv, C Xin, C Tan… - Journal of Controlled …, 2023 - Elsevier
In recent years, adeno-associated virus (AAV) has become the most important vector for
central nervous system (CNS) gene therapy. AAV has already shown promising results in …
central nervous system (CNS) gene therapy. AAV has already shown promising results in …
Overcoming the Blood–Brain Barrier for Gene Therapy via Systemic Administration of GSH‐Responsive Silica Nanocapsules
CRISPR genome editing can potentially treat the root causes of many genetic diseases,
including central nervous system (CNS) disorders. However, the promise of brain‐targeted …
including central nervous system (CNS) disorders. However, the promise of brain‐targeted …
Nanobiomaterial vectors for improving gene editing and gene therapy
SW Hu, T Ding, H Tang, H Guo, W Cui, Y Shu - Materials Today, 2023 - Elsevier
With the development of genome editing techniques, gene therapy is becoming a viable
option for the treatment of a variety of human diseases. Genome editing techniques mainly …
option for the treatment of a variety of human diseases. Genome editing techniques mainly …
[HTML][HTML] A multifaceted approach to optimizing AAV delivery to the brain for the treatment of neurodegenerative diseases
JM Fischell, PS Fishman - Frontiers in neuroscience, 2021 - frontiersin.org
Despite major advancements in gene therapy technologies, there are no approved gene
therapies for diseases which predominantly effect the brain. Adeno-associated virus (AAV) …
therapies for diseases which predominantly effect the brain. Adeno-associated virus (AAV) …
Interleukin-4 as a therapeutic target
Abstract Interleukin-4 (IL-4) is a pleiotropic cytokine mainly known for its role in type 2
immunity. Therapies antagonizing or blocking IL-4 activity have been developed to …
immunity. Therapies antagonizing or blocking IL-4 activity have been developed to …
Neurodegenerative disorders management: state-of-art and prospects of nano-biotechnology
Neurodegenerative disorders (NDs) are highly prevalent among the aging population. It
affects primarily the central nervous system (CNS) but the effects are also observed in the …
affects primarily the central nervous system (CNS) but the effects are also observed in the …
Mitochondrial dysfunction and neurological disorders: A narrative review and treatment overview
Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …
[HTML][HTML] From junk to function: LncRNAs in CNS health and disease
R Policarpo, A Sierksma, B De Strooper… - Frontiers in molecular …, 2021 - frontiersin.org
Recent advances in RNA sequencing technologies helped to uncover the existence of tens
of thousands of long non-coding RNAs (lncRNAs) that arise from the dark matter of the …
of thousands of long non-coding RNAs (lncRNAs) that arise from the dark matter of the …
[PDF][PDF] Rebuilding essential active zone functions within a synapse
Presynaptic active zones are molecular machines that control neurotransmitter secretion.
They form sites for vesicle docking and priming and couple vesicles to Ca 2+ entry for …
They form sites for vesicle docking and priming and couple vesicles to Ca 2+ entry for …