Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

The reprogramming of parental methylomes is essential for embryonic development. In
mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

PPCPs (pharmaceutical and personal care products) and microplastics (MPs) are two types
of emerging pollutants that are ubiquitous and widely concerned in the environment. Both of …

The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …

Zebrafish, a popular organism for studying embryonic development and for modeling human
diseases, has so far lacked a systematic functional annotation program akin to those in other …

After fertilization, maternal factors direct development and trigger zygotic genome activation
(ZGA) at the maternal-to-zygotic transition (MZT). In zebrafish, ZGA is required for …

Environmental sex determination (ESD) occurs in divergent, phylogenetically unrelated taxa,
and in some species, co-occurs with genetic sex determination (GSD) mechanisms …

The heart is a highly specialized organ with essential function for the organism throughout
life. The significance of DNA methylation in shaping the phenotype of the heart remains only …

Epigenetic mechanisms are proposed as an important way in which the genome responds
to the environment. Epigenetic marks, including DNA methylation and Histone modifications …