Improved model systems to predict drug efficacy, interactions, and drug-induced kidney
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …

The field of tissue engineering has advanced over the past decade, but the largest impact on
human health should be achieved with the transition of engineered solid organs to the clinic …

Kidney cells and tissues derived from human pluripotent stem cells (hPSCs) may enable
organ regeneration, disease modeling and drug screening. We report an efficient …

Summary Recapitulating three-dimensional (3D) structures of complex organs, such as the
kidney, from pluripotent stem cells (PSCs) is a major challenge. Here, we define the …

The generation of organoids is one of the biggest scientific advances in regenerative
medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were …

With the prevalence of end-stage renal disease rising 8% per annum globally, there is an
urgent need for renal regenerative strategies. The kidney is a mesodermal organ that …

Diseases affecting the kidney constitute a major health issue worldwide. Their incidence and
poor prognosis affirm the urgent need for the development of new therapeutic strategies …

Human pluripotent stem cells (hPSCs) can generate a diversity of cell types, but few
methods have been developed to derive cells of the kidney lineage. Here, we report a highly …

A variety of protocols have been developed that demonstrate the capability to differentiate
human pluripotent stem cells (hPSCs) into kidney structures. Our goal was to develop a high …

Human pluripotent stem cells (hPSCs) hold great promise for understanding kidney
development and disease. We reproducibly differentiated three genetically distinct wild-type …