The term frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders characterized mainly by atrophy of the frontal and anterior temporal lobes. Based …

Background A hexanucleotide repeat expansion in the first intron of C9ORF72 has been
shown to be responsible for a high number of familial cases of amyotrophic lateral sclerosis …

Many cells of the nervous system have been shown to release exosomes, a subclass of
secreted vesicles of endosomal origin capable of transferring biomolecules among cells: this …

It is well known that progranulin protein is involved in wound repair, inflammation, and tumor
formation. The wedding between progranulin and brain was celebrated in 2006 with the …

Progranulin (Pgrn) is a 88 kDa secreted protein with pleiotropic functions including
regulation of cell cycle progression, cell motility, wound repair and tumorigenesis. Using …

Background: Genetic testing of familial Alzheimer's disease (AD) and frontotemporal lobar
degeneration (FTLD) is attracting interest thanks to innovative primary prevention clinical …

Progranulin gene (GRN) mutations cause frontotemporal lobar degeneration (FTLD) with
TDP43-positive inclusions, although its clinical phenotype is heterogeneous and includes …

Progranulin is a growth factor involved in the regulation of multiple processes including
tumorigenesis, wound repair, development, and inflammation. The recent discovery that …

The genetics of neurodegenerative diseases has an important role to clarify the
pathogenetic mechanism, the diagnosis and finally the therapeutic and ethical implications …

Mutations in the progranulin gene (GRN) were first implicated in frontotemporal lobar
degeneration in 2006. The GRN p. Leu271LeufsX10 mutation is one of the most common …