The effect of the bacterial heat-stable nucleoid-structuring (H-NS) protein on gene
expression is overwhelmingly negative and extends throughout the genome, pointing to an …

Lateral gene transfer has played a prominent role in bacterial evolution, but the mechanisms
allowing bacteria to tolerate the acquisition of foreign DNA have been incompletely defined …

How genomes are organized within cells and how the 3D architecture of a genome
influences cellular functions are significant questions in biology. A bacterial genomic DNA …

Inheritable bacterial defence systems against phage infection and foreign DNA, termed
CRISPR (clustered regularly interspaced short palindromic repeats), consist of cas protein …

The recently discovered prokaryotic CRISPR/Cas defence system provides immunity against
viral infections and plasmid conjugation. It has been demonstrated that in Escherichia coli …

Regulation of virulence gene expression in enteropathogenic Escherichia coli (EPEC) and
enterohemorrhagic E. coli (EHEC) is incompletely understood. In EPEC, the plasmid …

Despite many years of intense work investigating the function of nucleoid‐associated
proteins in prokaryotes, their role in bacterial physiology remains largely unknown. The two …

Abstract The Escherichia coli H-NS protein is a nucleoid-associated protein involved in gene
regulation and DNA compaction. To get more insight into the mechanism of DNA …

Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

The acquisition of new genetic traits by horizontal gene transfer and their incorporation into
preexisting regulatory networks have been essential events in the evolution of bacterial …