Factor XI inhibitors: cardiovascular perspectives

R De Caterina, D Prisco… - European Heart …, 2023 - academic.oup.com
Anticoagulants are the cornerstone for prevention and treatment of thrombosis but are not
completely effective, and concerns about the risk of bleeding continue to limit their uptake …

How to optimize activated partial thromboplastin time (APTT) testing: solutions to establishing and verifying normal reference intervals and assessing APTT reagents …

EJ Favaloro, G Kershaw… - … in thrombosis and …, 2019 - thieme-connect.com
The activated partial thromboplastin time (APTT) assay is a very common coagulation test,
used for several reasons. The test is conventionally used for assessing the contact factor …

Current and emerging direct oral anticoagulants: state-of-the-art

G Lippi, R Gosselin, EJ Favaloro - Seminars in thrombosis and …, 2019 - thieme-connect.com
Anticoagulant drugs comprise a specific subcategory of antithrombotic agents that act to
inhibit blood coagulation at various stages, reducing clot development and ultimately …

[HTML][HTML] A review of guidelines on anticoagulation reversal across different clinical scenarios–Is there a general consensus?

TJ Milling, CV Pollack - The American journal of emergency medicine, 2020 - Elsevier
Anticoagulation is key to the treatment/prevention of thromboembolic events. The primary
complication of anticoagulation is serious or life-threatening hemorrhage, which may …

Major gastrointestinal bleeding risk with direct oral anticoagulants: Does type and dose matter?–A systematic review and network meta-analysis

D Radadiya, K Devani, B Brahmbhatt… - European Journal of …, 2021 - journals.lww.com
The relative risk of major gastrointestinal bleeding (GIB) among different direct oral
anticoagulants (DOACs) is debatable. Randomized controlled trials (RCTs) comparing …

Laboratory hemostasis: from biology to the bench

G Lippi, EJ Favaloro - Clinical Chemistry and Laboratory Medicine …, 2018 - degruyter.com
Physiological hemostasis is an intricate biological system, where procoagulant and
anticoagulant forces interplay and preserves blood fluidity when blood vessels are intact, or …

[HTML][HTML] Distinct pleiotropic effects of direct oral anticoagulants on cultured endothelial cells: a comprehensive review

N Atzemian, D Kareli, G Ragia… - Frontiers in …, 2023 - frontiersin.org
Direct Oral Anticoagulants (DOACs) have simplified the treatment of thromboembolic
disease. In addition to their established anticoagulant effects, there are indications from …

Impact of anticoagulation and antiplatelet drugs on surgery rates and mortality in trauma patients

FM Bläsius, M Laubach, H Andruszkow, C Lübke… - Scientific Reports, 2021 - nature.com
Preinjury anticoagulation therapy (AT) is associated with a higher risk for major bleeding.
We aimed to evaluated the influence of preinjury anticoagulant medication on the clinical …

Systematic review and meta-analysis of the efficacy and safety of apixaban compared to rivaroxaban in acute VTE in the real world

MR Aryal, R Gosain, A Donato, H Yu, A Katel… - Blood …, 2019 - ashpublications.org
Both apixaban and rivaroxaban have been approved for use in acute venous
thromboembolism (VTE). Although indirect comparison through network meta-analyses of …

Google Trends data reveal a sharp trend: teeth and claws attract more interest than feathers, hooves or fins

B Holmes, A Strzelecki, S Springer… - Environmental …, 2022 - cambridge.org
In nature conservation, the generation of public interest, attention or emotions is an
important instrument for nature, biotope and species protection; in this, charismatic flagship …