Cellular commitment to a specific lineage is controlled by differential silencing of genes,
which in turn depends on epigenetic processes such as DNA methylation and histone …

Genomic imprinting is a complex epigenetic process that contributes substantially to
embryogenesis, reproduction, and gametogenesis. Only small fraction of genes within the …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

Importance Intracytoplasmic sperm injection (ICSI) is increasingly used in patients without
severe male factor infertility without clear evidence of a benefit over conventional in vitro …

OBJECTIVE Fixed genomic variation explains only a small proportion of the risk of adiposity.
In animal models, maternal diet alters offspring body composition, accompanied by …

Differential methylation between the two alleles of a gene has been observed in imprinted
regions, where the methylation of one allele occurs on a parent-of-origin basis, the inactive …

Exposure to endocrine disruptors is associated with developmental defects. One compound
of concern, to which humans are widely exposed, is bisphenol A (BPA). In model organisms …

Purpose Methylation of sperm DNA is impaired in many infertile men potentially adversely
effecting reproductive outcomes. In somatic cells oxidative damage to DNA and …

Genomic imprinting, a process of epigenetic modification which allows the gene to be
expressed in a parent-of-origin specific manner, has an essential role in normal growth and …

BACKGROUND An estimated 3.5 million children have been born to date using assisted
reproduction technologies. We reviewed the data in order to evaluate current knowledge of …