Background LTX-315 is an oncolytic peptide deriving from bovine lactoferrin, with the ability
to induce cancer immunogenic cell death. However, the mechanism used by LTX-315 to …

Simple Summary We here show that CD169+ TAMs in primary breast tumors are associated
with tertiary lymphoid-like structures (TLLSs), Treg and Breg signatures, and a worse …

Colorectal cancer (CRC) remains a challenging and deadly disease with high tumor
microenvironment (TME) heterogeneity. Using an integrative multi-omics analysis and …

The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells
adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability …

Adoptive immunotherapy expressing synthetic chimeric antigen receptors (CAR) on T cells
through in vitro modifications represents a new and innovative strategy in cancer treatment …

Introduction Proprotein convertase subtilisin/kexin-9 (PCSK9) has been primarily studied in
the cardiovascular field however, its role in cancer pathophysiology remains incompletely …

Currently, tumor treatment research still focuses on the cancer cells themselves, but the fact
that the immune system plays an important role in inhibiting tumor development cannot be …

Malignant tumors have a unique tumor microenvironment (TME), which includes mild acidity,
hypoxia, overexpressed reactive oxygen species (ROS), and high glutathione (GSH) levels …

Background Drug resistance is a critical obstacle in cancer therapy. Discovering cancer drug
response is important to improve anti-cancer drug treatment and guide anti-cancer drug …

Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer,
which is relatively resistant to anti-programmed cell death-1 (α-PD1) therapy, characterized …