Role of Immune Checkpoint Inhibitor Therapy in Advanced EGFR-Mutant Non-Small Cell Lung Cancer

N Wiest, U Majeed, K Seegobin, Y Zhao, Y Lou… - Frontiers in …, 2021 - frontiersin.org
Over the last decade, the treatment of advanced non-small cell lung cancer (NSCLC) has
undergone rapid changes with innovations in oncogene-directed therapy and immune …

Combinatorial regimens of chemotherapeutic agents: A new perspective on raising the heat of the tumor immune microenvironment

J Liu, Y Yu, C Liu, C Gao, J Zhuang, L Liu… - Frontiers in …, 2022 - frontiersin.org
Harnessing the broad immunostimulatory capabilities of chemotherapy in combination with
immune checkpoint inhibitors has improved immunotherapy outcomes in patients with …

Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of …

J Jiao, Y Zhang, W Zhang, M He, M Meng… - Acta Pharmacologica …, 2024 - nature.com
Immunosuppression by the tumor microenvironment is a pivotal factor contributing to tumor
progression and immunotherapy resistance. Priming the tumor immune microenvironment …

The components of tumor microenvironment as biomarker for immunotherapy in metastatic renal cell carcinoma

J Su, L Zhou, Z Zhang, X Xiao, Y Qin, X Zhou… - Frontiers in …, 2023 - frontiersin.org
Substantial improvement in prognosis among metastatic renal cell carcinoma (mRCC)
patients has been achieved, owing to the rapid development and utilization of …

Association between circulating immune cells and the risk of prostate cancer: a Mendelian randomization study

X Hao, C Ren, H Zhou, M Li, H Zhang… - Frontiers in …, 2024 - frontiersin.org
Background There is still limited research on the association between immune cells and the
risk of prostate cancer. Further investigations are warranted to comprehend the intricate …

Drug resistance mechanism and reversal strategy in lung cancer immunotherapy

Y Xu, Y Liu, Y Ge, H Li, Y Zhang, L Wang - Frontiers in Pharmacology, 2023 - frontiersin.org
Among all malignant tumors, lung cancer has the highest mortality and morbidity rates. The
non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the most …

[HTML][HTML] Machine learning algorithm integrates bulk and single-cell transcriptome sequencing to reveal immune-related personalized therapy prediction features for …

L Zang, B Zhang, Y Zhou, F Zhang, X Tian… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) is a digestive malignancy with worse overall survival. Tumor immune
environment (TIME) alters the progression and proliferation of various solid tumors. Hence …

Update on autophagy inhibitors in cancer: opening up to a therapeutic combination with immune checkpoint inhibitors

E Bestion, E Raymond, S Mezouar, P Halfon - Cells, 2023 - mdpi.com
Autophagy is a highly conserved and natural degradation process that helps maintain cell
homeostasis through the elimination of old, worn, and defective cellular components …

Current state of knowledge and challenges for harnessing the power of dendritic cells in cancer immunotherapy

AM Shbeer - Pathology-Research and Practice, 2023 - Elsevier
DCs have great promise for cancer immunotherapy and are essential for coordinating
immune responses. In the battle against cancer, using DCs' ability to stimulate the immune …

A landscape of checkpoint blockade resistance in cancer: underlying mechanisms and current strategies to overcome resistance

GS Santiago-Sánchez, KP Fabian… - Cancer Biology & …, 2024 - Taylor & Francis
The discovery of immune checkpoints and the development of immune checkpoint inhibitors
(ICI) have achieved a durable response in advanced-stage cancer patients. However, there …