Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

The field of ageing research has been rapidly advancing in recent decades and it had
provided insight into the complexity of ageing phenomenon. However, as the organism …

Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes
mellitus, and atherosclerosis. In experimental models of neurodegenerative diseases, the …

Macrolides are widely used for the long-term treatment of infections and chronic
inflammatory diseases. The pharmacokinetic features of macrolides include extensive tissue …

Db/db mice (carrying a mutation in the gene encoding leptin receptor) show autophagy
suppression. Our aim was to evaluate the effect of autophagy inducer trehalose on liver and …

Abstract Nintedanib (NIN), a multi-tyrosine kinase inhibitor clinically approved for idiopathic
pulmonary fibrosis and lung cancer, is characterized by protonation-dependent …

Background: Alzheimer's disease (AD) is characterized by disrupted proteostasis and
macroautophagy (hereafter “autophagy”). The pharmacological agent suramin has known …

S. tetrandra is a traditional Chinese medicinal plant for pain relief and promote diuresis.
Tetrandrine (Tet) is a major component isolated from the herb. It is bisbenzylisoquinoline …