Vitamin D has a well-known role in the calcium homeostasis associated with the
maintenance of healthy bones. It increases the efficiency of the intestinal absorption of …

During the last two decades, the potential impact of vitamin D on the risk of cardiovascular
disease (CVD) has been rigorously studied. Data regarding the effect of vitamin D on CVD …

The activities of 1α, 25-dihydroxyvitamin D3, 1, 25D3, are mediated via its binding to the
vitamin D receptor (VDR), a ligand-dependent transcription factor that belongs to the nuclear …

Since calcium and phosphorus play vital roles in a multitude of physiologic systems,
disorders of calcium and phosphorus metabolism always lead to severe consequences such …

Zn2+, Mg2+, and Ca2+ are essential minerals required for a plethora of metabolic processes
and signaling pathways. Different categories of cation-selective channels and transporters …

Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

We provide an overview of the evidence for an erythropoietin-fibroblast growth factor 23
(FGF23) signaling pathway directly influencing erythroid cells in the bone marrow. We …

Vitamin D-dependent rickets type IA (VDDR-IA) is caused by biallelic mutations in CYP27B1.
Data regarding genotype–phenotype correlation in VDDR-IA are scarce. Here, we aimed to …

Introduction X-linked hypophosphatemia (XLH) is a rare inherited cause of
hypophosphatemic rickets and osteomalacia. It is caused by mutations in the phosphate …

ABSTRACT DMP1 (dentin matrix protein 1) is an extracellular matrix protein highly
expressed in bones. Studies of Dmp1 knockout (KO) mice led to the discovery of a rare …