Genetics of caffeine consumption and responses to caffeine
Rationale Caffeine is widely consumed in foods and beverages and is also used for a
variety of medical purposes. Despite its widespread use, relatively little is understood …
variety of medical purposes. Despite its widespread use, relatively little is understood …
Negative feedback control of neuronal activity by microglia
Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …
dying neurons, pruning non-functional synapses, and producing ligands that support …
Mechanisms for the Modulation of Dopamine D1 Receptor Signaling in Striatal Neurons
A Nishi, M Kuroiwa, T Shuto - Frontiers in neuroanatomy, 2011 - frontiersin.org
In the striatum, dopamine D1 receptors are preferentially expressed in striatonigral neurons,
and increase the neuronal excitability, leading to the increase in GABAergic inhibitory output …
and increase the neuronal excitability, leading to the increase in GABAergic inhibitory output …
Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum
A Nishi, M Kuroiwa, DB Miller… - Journal of …, 2008 - Soc Neuroscience
Phosphodiesterase (PDE) is a critical regulator of cAMP/protein kinase A (PKA) signaling in
cells. Multiple PDEs with different substrate specificities and subcellular localization are …
cells. Multiple PDEs with different substrate specificities and subcellular localization are …
PDE10A inhibitors: novel therapeutic drugs for schizophrenia
J Kehler, J Nielsen - Current pharmaceutical design, 2011 - ingentaconnect.com
Disturbances of the basal ganglia processes is heavily involved in schizophrenia.
Phosphodiesterase 10A (PDE10A) is a basal ganglia specific hydrolase, which plays an …
Phosphodiesterase 10A (PDE10A) is a basal ganglia specific hydrolase, which plays an …
Internalization and desensitization of adenosine receptors
EC Klaasse, AP IJzerman, WJ de Grip, MW Beukers - Purinergic signalling, 2008 - Springer
Until now, more than 800 distinct G protein-coupled receptors (GPCRs) have been identified
in the human genome. The four subtypes of the adenosine receptor (A 1, A 2A, A 2B and A 3 …
in the human genome. The four subtypes of the adenosine receptor (A 1, A 2A, A 2B and A 3 …
[HTML][HTML] Adenosine receptors: Emerging non-opioids targets for pain medications
Physical and emotional pain deteriorates the quality of well-being. Also, numerous non-
invasive and invasive treatments for diagnosed diseases such as cancer medications and …
invasive and invasive treatments for diagnosed diseases such as cancer medications and …
Indirect basal ganglia pathway mediation of repetitive behavior: attenuation by adenosine receptor agonists
Y Tanimura, S Vaziri, MH Lewis - Behavioural brain research, 2010 - Elsevier
Repetitive behaviors are diagnostic for autism and common in related neurodevelopmental
disorders. Despite their clinical importance, underlying mechanisms associated with the …
disorders. Despite their clinical importance, underlying mechanisms associated with the …
Adenosine A1-Dopamine D1 Receptor Heteromers Control the Excitability of the Spinal Motoneuron
M Rivera-Oliver, E Moreno, Y Álvarez-Bagnarol… - Molecular …, 2019 - Springer
While the role of the ascending dopaminergic system in brain function and dysfunction has
been a subject of extensive research, the role of the descending dopaminergic system in …
been a subject of extensive research, the role of the descending dopaminergic system in …
Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats
CL Adams, MS Cowen, JL Short… - International Journal of …, 2008 - academic.oup.com
Adenosine and glutamate have been implicated as mediators involved in the self-
administration of alcohol. In the present study we sought to determine whether adenosine …
administration of alcohol. In the present study we sought to determine whether adenosine …