Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

Q Wang, ZN Shen, SJ Zhang, Y Sun… - Frontiers in …, 2022 - frontiersin.org
Neurological diseases impose a tremendous and increasing burden on global health, and
there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried …

Syntaphilin mediates axonal growth and synaptic changes through regulation of mitochondrial transport: a potential pharmacological target for neurodegenerative …

QY Wu, HL Liu, HY Wang, KB Hu, P Liao… - Journal of Drug …, 2023 - Taylor & Francis
Mitochondria are a crucial energy source for maintaining neuronal growth and synaptic
function. Neurons possess unique morphological characteristics, which make the proper …

[PDF][PDF] SorCS2 binds progranulin to regulate motor neuron development

PB Thomasen, A Salasova, K Kjaer-Sorensen… - Cell Reports, 2023 - cell.com
Motor neuron (MN) development and nerve regeneration requires orchestrated action of a
vast number of molecules. Here, we identify SorCS2 as a progranulin (PGRN) receptor that …

Iridoids rich fraction from Valeriana jatamansi Jones promotes axonal regeneration and motor functional recovery after spinal cord injury through activation of the …

Y Wang, J Lu, H Xiao, L Ding, Y He… - Frontiers in Molecular …, 2024 - frontiersin.org
Valeriana jatamansi Jones (VJJ), renowned for its extensive history in traditional Chinese
medicine and ethnomedicine within China, is prevalently utilized to alleviate ailments such …

[HTML][HTML] Inhibition of spastin impairs motor function recovery after spinal cord injury

J Yang, Y Zhang, Z Cai, J Zou, S Li, G Miao, H Lin… - Brain Research …, 2023 - Elsevier
Promoting axonal regeneration is an effective strategy for recovery from traumatic spinal
cord injury (SCI). Spastin, a microtubule-severing protein, modulates axonal outgrowth and …

Sitagliptin attenuates neuronal apoptosis via inhibiting the endoplasmic reticulum stress after acute spinal cord injury

C Tang, T Xu, M Dai, X Zhong… - Human & …, 2023 - journals.sagepub.com
Regulation of endoplasmic reticulum stress (ER) stress-induced apoptosis and nerve
regeneration is a hopeful way for acute spinal cord injury (SCI). Sitagliptin (Sita) is one of …

Nanoparticles for the treatment of spinal cord injury

Q Yang, D Lu, J Wu, F Liang, H Wang, J Yang… - Neural Regeneration … - journals.lww.com
Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions,
presenting major challenges in neural regeneration. Achieving effective therapeutic …