A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease
VH Canela, WS Bowen, RM Ferreira, F Syed… - Nature …, 2023 - nature.com
Kidney stone disease causes significant morbidity and increases health care utilization. In
this work, we decipher the cellular and molecular niche of the human renal papilla in …
this work, we decipher the cellular and molecular niche of the human renal papilla in …
Pathophysiology and main molecular mechanisms of urinary stone formation and recurrence
F Tamborino, R Cicchetti, M Mascitti, G Litterio… - International Journal of …, 2024 - mdpi.com
Kidney stone disease (KSD) is one of the most common urological diseases. The incidence
of kidney stones has increased dramatically in the last few decades. Kidney stones are …
of kidney stones has increased dramatically in the last few decades. Kidney stones are …
Microbiology and immune mechanisms associated with male infertility
J Chen, J Chen, Y Fang, Q Shen, K Zhao… - Frontiers in …, 2023 - frontiersin.org
Up to 50% of infertility is caused by the male side. Varicocele, orchitis, prostatitis,
oligospermia, asthenospermia, and azoospermia are common causes of impaired male …
oligospermia, asthenospermia, and azoospermia are common causes of impaired male …
[HTML][HTML] Oxalate disrupts monocyte and macrophage cellular function via Interleukin-10 and mitochondrial reactive oxygen species (ROS) signaling
P Kumar, E Laurence, DK Crossman, DG Assimos… - Redox Biology, 2023 - Elsevier
Oxalate is a small compound found in certain plant-derived foods and is a major component
of calcium oxalate (CaOx) kidney stones. Individuals that consume oxalate enriched meals …
of calcium oxalate (CaOx) kidney stones. Individuals that consume oxalate enriched meals …
[HTML][HTML] Hydroxyproline stimulates inflammation and reprograms macrophage signaling in a rat kidney stone model
Meals rich in oxalate are associated with calcium oxalate (CaOx) kidney stone disease.
Hydroxy-L-proline (HLP) is an oxalate precursor found in milk and collagen-containing …
Hydroxy-L-proline (HLP) is an oxalate precursor found in milk and collagen-containing …
The role of microbiome: a novel insight into urolithiasis
SY Hong, QD Xia, YY Yang, C Li… - Critical Reviews in …, 2023 - Taylor & Francis
Urolithiasis, referred to as the formation of stones in the urinary tract, is a common disease
with growing prevalence and high recurrence rate worldwide. Although researchers have …
with growing prevalence and high recurrence rate worldwide. Although researchers have …
Inflammation and kidney stones: cause and effect?
G Capolongo, PM Ferraro, R Unwin - Current Opinion in Urology, 2023 - journals.lww.com
This concept is not new and raises the possibility that targeting inflammation directly may
prove to be a novel and suitable means of treatment for at least some types of kidney stone …
prove to be a novel and suitable means of treatment for at least some types of kidney stone …
A mechanistic insight into Beneficial effects of polyphenols in the Prevention and Treatment of Nephrolithiasis: evidence from recent in Vitro studies
M Hefer, IM Huskic, A Petrovic, N Raguz-Lucic… - Crystals, 2023 - mdpi.com
Nephrolithiasis is a pathological condition characterized by the formation of solid crystals in
the kidneys or other parts of urinary tract. Kidney stones are a serious public health issue …
the kidneys or other parts of urinary tract. Kidney stones are a serious public health issue …
Integrated single-nucleus sequencing and spatial architecture analysis identified distinct injured-proximal tubular types in calculi rats
Z Wang, Q Deng, Y Gu, M Li, Y Chen, J Wang… - Cell & Bioscience, 2023 - Springer
Background Urolithiasis with high prevalence and recurrence rate, has impacts on kidney
injury in patients, becomes a socioeconomic and healthcare problem in worldwide …
injury in patients, becomes a socioeconomic and healthcare problem in worldwide …
The advances of calcium oxalate calculi associated drugs and targets
Y Lai, H Zheng, X Sun, J Lin, Q Li, H Huang… - European Journal of …, 2022 - Elsevier
Kidney stones constitute a disease of the urinary system of high incidence that has only a
few available stone dissolving drugs as treatment options. The mechanism of calcium …
few available stone dissolving drugs as treatment options. The mechanism of calcium …