[HTML][HTML] Therapeutic peptides: Historical perspectives, current development trends, and future directions

JL Lau, MK Dunn - Bioorganic & medicinal chemistry, 2018 - Elsevier
Peptide therapeutics have played a notable role in medical practice since the advent of
insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and …

Biosurfactants produced by Serratia species: Classification, biosynthesis, production and application

T Clements, T Ndlovu, S Khan, W Khan - Applied microbiology and …, 2019 - Springer
Biosurfactants are surface-active molecules that are synthesised non-ribosomally by a wide
range of microorganisms including bacteria, yeast and filamentous fungi. The bacterial …

Retrospective analysis of natural products provides insights for future discovery trends

CR Pye, MJ Bertin, RS Lokey… - Proceedings of the …, 2017 - National Acad Sciences
Understanding of the capacity of the natural world to produce secondary metabolites is
important to a broad range of fields, including drug discovery, ecology, biosynthesis, and …

[HTML][HTML] Imaging the unimaginable: desorption electrospray ionization–imaging mass spectrometry (DESI-IMS) in natural product research

D Parrot, S Papazian, D Foil, D Tasdemir - Planta medica, 2018 - thieme-connect.com
Imaging mass spectrometry (IMS) has recently established itself in the field of “spatial
metabolomics.” Merging the sensitivity and fast screening of high-throughput mass …

[HTML][HTML] Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)

F Maglangit, Y Yu, H Deng - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to the second quarter of 2020 Threat or treat? While pathogenic bacteria pose
significant threats, they also represent a huge reservoir of potential pharmaceuticals to treat …

[HTML][HTML] Broad-spectrum antimicrobial activity of secondary metabolites produced by Serratia marcescens strains

T Clements, T Ndlovu, W Khan - Microbiological research, 2019 - Elsevier
The genus Serratia is a predominantly unexplored source of antimicrobial secondary
metabolites. The aim of the current study was thus to isolate and evaluate the antimicrobial …

[HTML][HTML] A Metabolomics and Molecular Networking Approach to Elucidate the Structures of Secondary Metabolites Produced by Serratia marcescens Strains

T Clements, M Rautenbach, T Ndlovu, S Khan… - Frontiers in …, 2021 - frontiersin.org
An integrated approach that combines reverse-phase high-performance liquid
chromatography (RP-HPLC), electrospray ionization mass spectrometry, untargeted ultra …

[HTML][HTML] Road kills in tropical ecosystems: a review with recommendations for mitigation and for new research

J Monge-Nájera - Revista de biologia tropical, 2018 - scielo.sa.cr
Si bien los caminos son indispensables para la civilización moderna y benefician a muchas
especies de vida silvestre, han estado causando mortalidad por atropello desde que se …

Metabolomics and Genomics Approach for the Discovery of Serrawettin W2 Lipopeptides from Serratia marcescens NP2

T Clements-Decker, M Rautenbach… - Journal of Natural …, 2022 - ACS Publications
A metabolomics/peptidomics and genomics approach, using UPLC-MSE, molecular
networking, and genome mining, was used to describe the serrawettin W2 lipopeptide family …

Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile

JL Ochoa, LM Sanchez, BM Koo… - ACS infectious …, 2018 - ACS Publications
The recent explosion of research on the microbiota has highlighted the important interplay
between commensal microorganisms and the health of their cognate hosts. Metabolites …