The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Cerebral small vessel disease (CSVD) is the most common, chronic and progressive
vascular disease. The changes affect arterioles, capillaries and small veins supplying the …

Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects
approximately 24% to 40% of the population of the Western world. In addition to its well …

Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …

The neurovascular system (NVS), which consisted of neurons, glia, and vascular cells, is a
functional and structural unit of the brain. The NVS regulates blood-brain barrier (BBB) …

The neurovascular unit (NVU) is a relatively recent concept that clearly describes the
relationship between brain cells and their blood vessels. The components of the NVU …

Cognitive impairment and dementia are burgeoning public health concerns, especially
given the increasing longevity of the global population. These conditions not only affect the …

Age-related blood-brain barrier (BBB) disruption and cerebromicrovascular rarefaction
contribute importantly to the pathogenesis of both vascular cognitive impairment and …

Introduction Emerging evidence has suggested that cerebral small vessel disease (CSVD)
may worsen motor function and cognition in Parkinson's disease (PD). However, the effect of …

Age-related cerebrovascular pathologies, ranging from cerebromicrovascular functional and
structural alterations to large vessel atherosclerosis, promote the genesis of vascular …