Organoids: The current status and biomedical applications
S Yang, H Hu, H Kung, R Zou, Y Dai, Y Hu… - MedComm, 2023 - Wiley Online Library
Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …
3D lung tissue models for studies on SARS-CoV-2 pathophysiology and therapeutics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the coronavirus
disease 2019 (COVID-19), has provoked more than six million deaths worldwide and …
disease 2019 (COVID-19), has provoked more than six million deaths worldwide and …
Human Lung Organoids—A Novel Experimental and Precision Medicine Approach
L Kühl, P Graichen, N von Daacke, A Mende… - Cells, 2023 - mdpi.com
The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …
need for accurate models for basic and translational research. Several model systems are …
Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts
CE Edwards, A Tata, RS Baric - Translational Research, 2022 - Elsevier
Human respiratory viruses induce a wide breadth of disease phenotypes and outcomes of
varying severity. Innovative models that recapitulate the human respiratory tract are needed …
varying severity. Innovative models that recapitulate the human respiratory tract are needed …
[HTML][HTML] Human lung organoid: Models for respiratory biology and diseases
W Yang, Y Li, F Shi, H Liu - Developmental Biology, 2023 - Elsevier
The human respiratory system, consisting of the airway and alveoli, is one of the most
complex organs directly interfaced with the external environment. The diverse epithelial cells …
complex organs directly interfaced with the external environment. The diverse epithelial cells …
Recent frontiers in biofabrication for respiratory tissue engineering
Respiratory tissue engineering offers a robust framework for studying cell-cell and host-
pathogen interactions in a tissue-like environment and offers a platform for studying lung …
pathogen interactions in a tissue-like environment and offers a platform for studying lung …
Organoids as a novel tool in modelling infectious diseases
LF de Oliveira, D Mendes Filho, BL Marques… - Seminars in cell & …, 2023 - Elsevier
Infectious diseases worldwide affect human health and have important societal impacts. A
better understanding of infectious diseases is urgently needed. In vitro and in vivo infection …
better understanding of infectious diseases is urgently needed. In vitro and in vivo infection …
In vitro high-content tissue models to address precision medicine challenges
The field of precision medicine allows for tailor-made treatments specific to a patient and
thereby improve the efficiency and accuracy of disease prevention, diagnosis, and treatment …
thereby improve the efficiency and accuracy of disease prevention, diagnosis, and treatment …
NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids
CR Simoneau, PY Chen, GK Xing, JM Hayashi… - Scientific Reports, 2024 - nature.com
As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that
recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe …
recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe …
The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells
L Bauer, LC Rijsbergen, L Leijten… - Life Science …, 2023 - life-science-alliance.org
Morbidity and mortality from influenza are associated with high levels of systemic
inflammation. Endothelial cells play a key role in systemic inflammatory responses during …
inflammation. Endothelial cells play a key role in systemic inflammatory responses during …