Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well
as in chronic pain therapy because it has both anaesthetic and analgesic‐sparing activity …

Objective To review previous work and present additional evidence characterizing the I 1-
imidazoline receptor and its role in cellular signaling, central cardiovascular control, and the …

Dexmedetomidine is a selective alpha 2-adrenoceptor agonist with centrally mediated
sympatholytic, sedative, and analgesic effects. This study evaluated: 1) pharmacokinetics of …

Background Alpha 2-adrenergic agonists decrease sympathetic tone with ensuing
attenuation of neuroendocrine and hemodynamic responses to anesthesia and surgery. The …

Dexmedetomidine is a highly selective alpha 2-adrenoceptor agonist with anaesthetic-
sparing effects. We have determined the pharmacodynamic and pharmacokinetic …

In this prospective study, we evaluated whether high thoracic epidural anesthesia (TEA) or
IV clonidine, in addition to general anesthesia, affects the cardiopulmonary bypass-and …

In a double-blinded trial, 40 male children (age 2–7 yr) undergoing circumcision were
randomly assigned to receive clonidine 2 μg/kg IV or placebo after anesthetic induction. For …

Ischemia-reperfusion (IR) injury remains the leading cause of acute renal failure. The
purpose of this experimental study was to determine the role of dexmedetomidine on …

OBJECTIVES Acute kidney failure after coronary artery bypass grafting (CABG) is a serious
complication that increases morbidity and mortality rates. Early detection and prevention of …

Preoperative alpha sub 2-adrenergic receptor agonists preven... : Critical Care Medicine
Preoperative alpha sub 2-adrenergic receptor agonists prevent the deterioration of renal …