Functional screening of expression libraries in vivo would offer the possibility of identifying
novel biotherapeutics without a priori knowledge of their biochemical function. Here we …

Desacyl-ghrelin is a form of ghrelin which lacks acyl-modification of the third serine residue
of ghrelin. Originally, desacyl-ghrelin was considered to be just an inactive form of ghrelin …

MicroRNAs (miRNAs and miRs) are endogenous 19–22 nucleotide, small noncoding RNAs
with highly conservative and tissue specific expression. They can negatively modulate target …

With our aging society, more people hope for a long and healthy life. In recent years,
researchers have focused on healthy longevity factors. In particular, calorie restriction delays …

Sarcopenia, the decline in muscle mass and functionality during aging, might arise from age-
associated endocrine dysfunction. Ghrelin is a hormone circulating in both acylated (AG) …

Pulsed electromagnetic fields (PEMF) are employed as a non-invasive medicinal therapy,
especially in the orthopedic field to stimulate bone regeneration. However, the effect of …

Ghrelin is a gastric hormone circulating in acylated (AG) and unacylated (UnAG) forms. This
narrative review aims at presenting current emerging knowledge on the impact of ghrelin …

Despite being unable to activate the cognate ghrelin receptor (GHS-R), unacylated ghrelin
(UAG) possesses a unique activity spectrum that includes promoting bone marrow …

Hibernating brown bears, Ursus arctos, undergo extended periods of inactivity and yet these
large hibernators are resilient to muscle disuse atrophy. Physiological characteristics …

Current therapeutic strategies for the treatment of critical limb ischemia (CLI) have only
limited success. Recent in vitro evidence in the literature, using cell lines, proposes that the …