Posttranslational control of HuR function

I Grammatikakis, K Abdelmohsen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …

Post-translational control of RNA-binding proteins and disease-related dysregulation

A Velázquez-Cruz, B Baños-Jaime… - Frontiers in molecular …, 2021 - frontiersin.org
Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …

Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers

K Masuda, Y Kuwano - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
Gene expression patterns in cancer cells are strongly influenced by posttranscriptional
mechanisms. RNA‐binding proteins (RBPs) play key roles in posttranscriptional gene …

PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

Y Ke, Y Han, X Guo, J Wen, K Wang, X Jiang… - Nature …, 2017 - nature.com
Abstract Poly (ADP-ribosyl) ation (PARylation) is mainly catalysed by poly-ADP-ribose
polymerase 1 (PARP1), whose role in gene transcription modulation has been well …

Hallmarks of cancer and AU‐rich elements

KSA Khabar - Wiley Interdisciplinary Reviews: RNA, 2017 - Wiley Online Library
Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained
stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU …

Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells

M Dovizio, TJ Maier, S Alberti, L Di Francesco… - Molecular …, 2013 - ASPET
Cyclooxygenase (COX)-2–derived prostanoids can influence several processes that are
linked to carcinogenesis. We aimed to address the hypothesis that platelets contribute to …

[HTML][HTML] Human antigen R as a therapeutic target in pathological cardiac hypertrophy

LC Green, SR Anthony, S Slone, L Lanzillotta… - JCI insight, 2019 - ncbi.nlm.nih.gov
RNA binding proteins represent an emerging class of proteins with a role in cardiac
dysfunction. We show that activation of the RNA binding protein human antigen R (HuR) is …

Clinical significance of HuR expression in human malignancy

I Kotta-Loizou, C Giaginis, S Theocharis - Medical oncology, 2014 - Springer
Hu-antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and
nucleus-to-cytoplasm translocation of target mRNAs. The aim of the present review was to …

mRNA post-transcriptional regulation by AU-rich element-binding proteins in liver inflammation and cancer

D Dolicka, C Sobolewski, M Correia de Sousa… - International journal of …, 2020 - mdpi.com
AU-rich element-binding proteins (AUBPs) represent important post-transcriptional
regulators of gene expression. AUBPs can bind to the AU-rich elements present in the 3' …

The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets

RM Scheiba, AI de Opakua, A Díaz-Quintana… - RNA biology, 2014 - Taylor & Francis
Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …