The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

EMT factors and metabolic pathways in cancer

I Georgakopoulos-Soares, DV Chartoumpekis… - Frontiers in …, 2020 - frontiersin.org
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Epithelial–mesenchymal transition and its transcription factors

P Debnath, RS Huirem, P Dutta… - Bioscience …, 2022 - portlandpress.com
Epithelial–mesenchymal transition or EMT is an extremely dynamic process involved in
conversion of epithelial cells into mesenchymal cells, stimulated by an ensemble of …

Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery

S Di Franco, P Bianca, DS Sardina, A Turdo… - Nature …, 2021 - nature.com
Obesity is a strong risk factor for cancer progression, posing obesity-related cancer as one of
the leading causes of death. Nevertheless, the molecular mechanisms that endow cancer …

The crucial role of ZEB2: from development to epithelial‐to‐mesenchymal transition and cancer complexity

M Fardi, M Alivand, B Baradaran… - Journal of cellular …, 2019 - Wiley Online Library
Zinc finger E‐box binding homeobox 2 (ZEB2) is a DNA‐binding transcription factor, which
is mainly involved in epithelial‐to‐mesenchymal transition (EMT). EMT is a conserved …

Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway

R Xie, J Tang, X Zhu, H Jiang - Bioscience reports, 2019 - portlandpress.com
Abstract Background: Circular RNAs (circRNAs) have been reported as the competing
endogenous RNAs (ceRNAs) to sponge microRNAs (miRNAs) implicating in the initiation …

[HTML][HTML] Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR

H Schuhwerk, T Brabletz - Seminars in Cancer Biology, 2023 - Elsevier
TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …

[HTML][HTML] miR‑498 inhibits the growth and metastasis of liver cancer by targeting ZEB2

X Zhang, X Xu, G Ge, X Zang, M Shao… - Oncology …, 2019 - spandidos-publications.com
MicroRNAs (miRNAs) play critical roles in the growth, metastasis and therapeutic resistance
of liver cancer. Accumulating evidence suggests that miR‑498 is aberrantly expressed in …

MiR-454-3p and miR-374b-5p suppress migration and invasion of bladder cancer cells through targetting ZEB2

S Wang, G Zhang, W Zheng, Q Xue, D Wei… - Bioscience …, 2018 - portlandpress.com
Bladder cancer (BCa) threatens human health due to the high occurrence and mortality.
Nowadays, more and more researchers focussed on the molecular mechanisms and …

[HTML][HTML] DEP-induced ZEB2 promotes nasal polyp formation via epithelial-to-mesenchymal transition

M Lee, S Lim, YS Kim, R Khalmuratova, SH Shin… - Journal of Allergy and …, 2022 - Elsevier
Background Diesel exhaust particles (DEPs) are associated with the prevalence and
exacerbation of allergic respiratory diseases, including allergic rhinitis and allergic asthma …