[HTML][HTML] Synthesis, molecular docking, and biological evaluation of novel anthranilic acid hybrid and its diamides as antispasmodics
The present article focuses on the synthesis and biological evaluation of a novel anthranilic
acid hybrid and its diamides as antispasmodics. Methods: Due to the predicted in silico …
acid hybrid and its diamides as antispasmodics. Methods: Due to the predicted in silico …
[HTML][HTML] The role of myrrh metabolites in cancer, inflammation, and wound healing: prospects for a multi-targeted drug therapy
Background: Myrrh extract is a well-known medicinal plant with significant therapeutic
benefits attributed to the activity of its diverse metabolites. It has promising activity against …
benefits attributed to the activity of its diverse metabolites. It has promising activity against …
Computer-aided analysis for identification of novel analogues of ketoprofen based on molecular docking, ADMET, drug-likeness and DFT studies for the treatment of …
FZY Bettadj, W Benchouk - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
Computer-based drug design is increasingly used in strategies for discovering new
molecules for therapeutic purposes. The targeted drug is ketoprofen (KTP), which belongs to …
molecules for therapeutic purposes. The targeted drug is ketoprofen (KTP), which belongs to …
[HTML][HTML] In Silico, In Vitro, and Ex Vivo Biological Activity of Some Novel Mebeverine Precursors
Irritable bowel syndrome (IBS) is a functional gastroenterological disorder with complex
pathogenesis and multifaceted therapy approaches, aimed at alleviating clinical symptoms …
pathogenesis and multifaceted therapy approaches, aimed at alleviating clinical symptoms …
Influence of Different Ratios of DSPE-PEG2k on Ester Prodrug Self-Assembly Nanoparticles for Cell Migration and Proliferation Suppression
H Zhang, S Wei, Y Hu, Y Zhang, H Yao… - International Journal …, 2024 - Taylor & Francis
Background Bufalin (BFL, an active anti-tumor compound derived from toad venom) is
limited in its application due to high toxicity and rapid metabolism of the cardiotonic steroid …
limited in its application due to high toxicity and rapid metabolism of the cardiotonic steroid …
[HTML][HTML] 2-Amino-N-Phenethylbenzamides for Irritable Bowel Syndrome Treatment
Irritable bowel syndrome (IBS) is a common gastrointestinal (GI) disorder characterized by
abdominal pain or discomfort. Mebeverine is an antispasmodic that has been widely used in …
abdominal pain or discomfort. Mebeverine is an antispasmodic that has been widely used in …
[HTML][HTML] Antileishmanial Effect of 1, 5-and 1, 8-Substituted Fused Naphthyridines
E Melcón-Fernandez, E Martín-Encinas, F Palacios… - Molecules, 2023 - mdpi.com
In the absence of a vaccine, there is a need to find new drugs for the treatment of neglected
tropical diseases, such as leishmaniasis, that can overcome the many drawbacks of those …
tropical diseases, such as leishmaniasis, that can overcome the many drawbacks of those …
[HTML][HTML] Interleukin-10 as Covid-19 biomarker targeting KSK and its analogues: Integrated network pharmacology
COVID-19 caused by the SARS-CoV-2 virus is widespread in all regions, and it disturbs host
immune system functioning leading to extreme inflammatory reaction and hyperactivation of …
immune system functioning leading to extreme inflammatory reaction and hyperactivation of …
[HTML][HTML] Spasmolytic Activity of 1, 3-Disubstituted 3, 4-Dihydroisoquinolines
This article concerns the spasmolytic activities of some novel 1, 3-disubstituted 3, 4-
dihydroisoquinolines. These compounds can be evaluated as potential therapeutic …
dihydroisoquinolines. These compounds can be evaluated as potential therapeutic …
[HTML][HTML] Drug Discovery
S Nikolova - Applied Sciences, 2023 - mdpi.com
More than 50% of deaths worldwide are linked to chronic inflammatory disorders, including
cancer, cardiovascular disease, dementia, stroke, and diabetes. This makes inflammation …
cancer, cardiovascular disease, dementia, stroke, and diabetes. This makes inflammation …