Frontotemporal lobar degeneration (FTLD) is a clinically and pathologically heterogeneous
syndrome, characterized by progressive decline in behaviour or language associated with …

Low birth rates and increasing life expectancy experienced by developed societies have
placed an unprecedented pressure on governments and the health system to deal …

Apathy and impulsivity are common and disabling consequences of frontotemporal lobar
degeneration. They cause substantial carer distress, but their aetiology remains elusive …

There is increasing evidence that frontotemporal lobar degeneration (FTLD) and
amyotrophic lateral sclerosis (ALS) represent a continuum of neurodegenerative diseases …

TDP-43 is a multifunctional DNA/RNA-binding factor that has been implicated in the
regulation of neuronal plasticity. TDP-43 has also been identified as the major constituent of …

The British Association for Psychopharmacology (BAP) coordinated a meeting of experts to
review and revise its first (2006) Guidelines for clinical practice with anti-dementia drugs. As …

Frontotemporal dementia (FTD) is the second most common dementia before 65 years of
age. Haploinsufficiency in the progranulin (GRN) gene accounts for 10% of all cases of …

Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in
social and emotional function. Heterozygous loss-of-function mutations in GRN, the …

Tauopathies represent a group of neurodegenerative disorders characterized by the
accumulation of pathological TAU protein in brains. We report a human neuronal model of …

We tested the efficacy and tolerability of one-year treatment with memantine (10mg bid) in
behavioral variant frontotemporal dementia (bvFTD). BvFTD patients aged 45 to 75 years …