Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis,
wound healing, and several other biological functions and pathological conditions. The X …

Fibrin plays an essential role in hemostasis as both the primary product of the coagulation
cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly …

Since its discovery over 350 years ago, studies of fibrinogen have revealed remarkable
characteristics. Its complex structure as a large (340 kD a) hexameric homodimer supports …

Fibrinolysis appears in many diverse physiological situations, and the components of the
system are well established, along with mechanistic details for the individual reactions and …

Fibrinogen is a large glycoprotein, synthesized primarily in the liver. With a normal plasma
concentration of 1.5–3.5 g/L, fibrinogen is the most abundant blood coagulation factor. The …

We conducted a multicenter study of 101 patients with congenital dysfibrinogenemia (CD) to
characterize the incidence of hemorrhagic and thrombotic events as well as complications of …

Red Blood Cells (RBCs) have been increasingly recognized to play important roles in
hemostasis and the mechanisms by which they do so continue to be elucidated. First and …

The human commensal bacterium Staphylococcus aureus can cause a wide range of
infections ranging from skin and soft tissue infections to invasive diseases like septicemia …

Accumulating evidence indicates that accelerated formation of fibrin clots composed of
compact, highly-branched networks with thin fibres which are relatively resistant to plasmin …

Abnormal fibrin clot structure, in particular increased fibrin fiber density and stiffness and
resistance to fibrinolysis, are reported to be linked to cardiovascular disease (CVD) and a …