Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Glioblastoma multiforme is a central nervous system tumor of grade IV histological
malignancy according to the WHO classification. Over 90% of diagnosed glioblastomas …

Simple Summary The estimated survival time for glioblastoma patients is extremely low; only
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …

In contrast to almost all other brain tumors, diffuse gliomas infiltrate extensively in the
neuropil. This growth pattern is a major factor in therapeutic failure. Diffuse infiltrative glioma …

The invasive nature of brain-tumour cells makes an important contribution to the
ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

Mathematical modeling, analysis and simulation are set to play crucial roles in explaining
tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial …

Abstract Purpose: Methyl-[11C] l-methionine ([11C] MET) positron emission tomography
(PET) in brain tumors reflects amino acid transport and has been shown to be more sensitive …

Chlorotoxin is a small 36 amino-acid peptide identified from the venom of the scorpion
Leiurus quinquestriatus. Initially, chlorotoxin was used as a pharmacological tool to …

Learning Objectives After completing this course, the reader will be able to: Describe the
genetic alterations frequently observed in GBM tumors as well as the cell signal transduction …