The scientific basis of combination therapy for chronic hepatitis B functional cure
SG Lim, TF Baumert, C Boni, E Gane… - Nature Reviews …, 2023 - nature.com
Functional cure of chronic hepatitis B (CHB)—or hepatitis B surface antigen (HBsAg) loss
after 24 weeks off therapy—is now the goal of treatment, but is rarely achieved with current …
after 24 weeks off therapy—is now the goal of treatment, but is rarely achieved with current …
[HTML][HTML] Immune responses and immunopathology in acute and chronic viral hepatitis
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: a pilot study
Background & Aims To evaluate the hypothesis that increasing T cell frequency and activity
may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a …
may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a …
Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B
Hepatitis B virus (HBV)-specific CD8 T cells are functionally exhausted in chronic hepatitis B
infection, and this condition can be corrected only partially through the modulation of …
infection, and this condition can be corrected only partially through the modulation of …
Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells
B Rehermann - Nature medicine, 2013 - nature.com
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …
Hepatitis B virus infection
MF Yuen, DS Chen, GM Dusheiko… - Nature reviews Disease …, 2018 - nature.com
Hepatitis B virus (HBV) is a hepatotropic virus that can establish a persistent and chronic
infection in humans through immune anergy. Currently, 3.5% of the global population is …
infection in humans through immune anergy. Currently, 3.5% of the global population is …
[HTML][HTML] Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
JJ Park, EP Thi, VH Carpio, Y Bi, AG Cole… - Nature …, 2021 - nature.com
Programmed death-ligand 1 is a glycoprotein expressed on antigen presenting cells,
hepatocytes, and tumors which upon interaction with programmed death-1, results in …
hepatocytes, and tumors which upon interaction with programmed death-1, results in …
Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation
B Bengsch, B Martin, R Thimme - Journal of hepatology, 2014 - Elsevier
Background & Aims The upregulation of several inhibitory signalling pathways by exhausted
HBV-specific CD8+ T cells in chronic infection is thought to contribute to viral persistence …
HBV-specific CD8+ T cells in chronic infection is thought to contribute to viral persistence …
Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: the virus
can either replicate without pathological consequences or trigger immune-mediated …
can either replicate without pathological consequences or trigger immune-mediated …
Hepatitis B virus–specific and global T-cell dysfunction in chronic hepatitis B
Background & Aims T cells play a critical role in viral infection. We examined whether T-cell
effector and regulatory responses can define clinical stages of chronic hepatitis B (CHB) …
effector and regulatory responses can define clinical stages of chronic hepatitis B (CHB) …