[HTML][HTML] Human carboxylesterases: a comprehensive review

D Wang, L Zou, Q Jin, J Hou, G Ge, L Yang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Esterase is a powerful tool for the biodegradation of pyrethroid insecticides

P Bhatt, K Bhatt, Y Huang, Z Lin, S Chen - Chemosphere, 2020 - Elsevier
Agricultural and household applications of pyrethroid insecticides have significantly
increased residual concentrations in living cells and environments. The enhanced …

Long-term effect of plastic feeding on growth and transcriptomic response of mealworms (Tenebrio molitor L.)

Z Zhong, W Nong, Y Xie, JHL Hui, LM Chu - Chemosphere, 2022 - Elsevier
Plastic waste has been considered a serious global environmental problem for decades.
Despite the high recalcitrance of synthetic plastics, the biodegradation of polyethylene (PE) …

Carboxylesterase inhibitors: an update

LW Zou, Q Jin, DD Wang, QK Qian… - Current medicinal …, 2018 - ingentaconnect.com
Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …

Comprehensive study of sulfamethoxazole effects in marine mussels: Bioconcentration, enzymatic activities and metabolomics

A Serra-Compte, D Álvarez-Muñoz, M Solé… - Environmental …, 2019 - Elsevier
Antibiotics accumulation in aquatic organisms may be of great concern from an ecological
point of view but also from a human perspective, especially when they are accumulated in …

iTRAQ and PRM-based comparative proteomic profiling in gills of white shrimp Litopenaeus vannamei under copper stress

H Guo, T Chen, Z Liang, L Fan, Y Shen, D Zhou - Chemosphere, 2021 - Elsevier
Crustaceans are particularly sensitive to heavy metal pollution. Copper (Cu) is one of typical
heavy metal pollutants in aquatic ecosystems. However, limited attention has been paid on …

[HTML][HTML] Structure-activity relationships of pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1

LW Zou, TY Dou, P Wang, W Lei, ZM Weng… - Frontiers in …, 2017 - frontiersin.org
Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …

Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1, 3-dione scaffold

GF Makhaeva, SV Lushchekina, NP Boltneva… - European Journal of …, 2021 - Elsevier
An expanded series of alkyl 2-arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropionates
(HOPs) 3 was obtained via Cu (OAc) 2-catalyzed azo coupling. All were nanomolar …

Detection techniques of carboxylesterase activity: An update review

L Lan, X Ren, J Yang, D Liu, C Zhang - Bioorganic chemistry, 2020 - Elsevier
Mammalian carboxylesterases (CESs) are essential members of serine esterase hydrolase
superfamily, which are widely distributed in many tissues including liver, intestine, lung and …

[HTML][HTML] Powerful potential of polyfluoroalkyl-containing 4-arylhydrazinylidenepyrazol-3-ones for pharmaceuticals

YV Burgart, NA Elkina, EV Shchegolkov, OP Krasnykh… - Molecules, 2022 - mdpi.com
4-Arylhydrazinylidene-5-(polyfluoroalkyl) pyrazol-3-ones (4-AHPs) were found to be
obtained by the regiospecific cyclization of 2-arylhydrazinylidene-3-(polyfluoroalkyl)-3 …