Repurposing drugs by uncovering new indications for approved drugs accelerates the
process of establishing new treatments and reduces the high costs of drug discovery and …

Immune checkpoint inhibitors (ICI) have achieved unprecedented clinical success in cancer
treatment. However, drug resistance to ICI therapy is a major hurdle that prevents cancer …

Background The dismal prognosis of glioblastoma (GBM) may be related to the ability of
GBM cells to develop mechanisms of treatment resistance. We designed a protocol called …

Repurposing is a drug development strategy that seeks to use existing medications for new
indications. In oncology, there is an increased level of activity looking at the use of non …

The cost of cancer care accelerates because of the growing number of cancer patients and
the increasing expenses of drug innovations. The approval of costly second-line therapies …

Ovarian cancer is the seventh most common cancer and the eighth most common cause of
cancer mortality in women. Although standard chemotherapy is the established treatment for …

Maintenance therapy sometimes relies on the use of metronomic chemotherapy (MC); that
is, the continuous administration of low-dose chemotherapy. Maintenance therapy has been …

Drug repositioning refers to new uses for existing drugs outside the scope of the original
medical indications. This approach fastens the process of drug development allowing …

Gliomas are the most common primary central nervous system tumors; despite recent
advances in diagnosis and treatment, glioma patients generally have a poor prognosis …

Drug repurposing is a method of drug discovery that consists of finding a new therapeutic
context for an old drug. Compound identification arises from screening of large libraries of …