WikiPathways 2024: next generation pathway database

A Agrawal, H Balcı, K Hanspers, SL Coort… - Nucleic acids …, 2024 - academic.oup.com
WikiPathways (wikipathways. org) is an open-source biological pathway database.
Collaboration and open science are pivotal to the success of WikiPathways. Here we …

PathDIP 5: improving coverage and making enrichment analysis more biologically meaningful

C Pastrello, M Kotlyar, M Abovsky, R Lu… - Nucleic Acids …, 2024 - academic.oup.com
Abstract Pathway Data Integration Portal (PathDIP) is an integrated pathway database that
was developed to increase functional gene annotation coverage and reduce bias in …

Inference of differential key regulatory networks and mechanistic drug repurposing candidates from scRNA-seq data with SCANet

M Oubounyt, L Adlung, F Patroni, NK Wenke… - …, 2023 - academic.oup.com
Motivation The reconstruction of small key regulatory networks that explain the differences in
the development of cell (sub) types from single-cell RNA sequencing is a yet unresolved …

[HTML][HTML] Proteomic meta-study harmonization, mechanotyping and drug repurposing candidate prediction with ProHarMeD

K Adamowicz, L Arend, A Maier, JR Schmidt… - npj Systems Biology …, 2023 - nature.com
Proteomics technologies, which include a diverse range of approaches such as mass
spectrometry-based, array-based, and others, are key technologies for the identification of …

HerpesFolds: A proteome-wide structural systems approach reveals insights into protein families and activities of all nine human herpesviruses

TK Soh, S Ognibene, S Sanders, BB Kaufer, JB Bosse - bioRxiv, 2024 - biorxiv.org
Structure predictions have become invaluable tools for wet lab science by accelerating the
generation of structure-based hypotheses. While AlphaFold-predicted structures are …

SCANET for single-cell network-based drug repurposing candidate extraction

M Oubounyt, L Adlung, F Patroni, NK Wenke, A Maier… - drugrepocentral.scienceopen.com
Reconstructing small regulatory networks is essential for understanding cellular functions
and mechanisms. Performing this task with single-cell RNA sequencing data poses a …