This guidance provides a data-supported approach to the diagnosis, staging, and treatment
of patients diagnosed with hepatocellular carcinoma (HCC). A guidance document is …

On the global scale, hepatitis B virus (HBV) infection is the main cause of hepatocellular
carcinoma (HCC) especially in regions of Asia where HBV infection is endemic …

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and one of the
leading causes of cancer-related death worldwide. HCC is highly heterogeneous, both …

Abstract Background & Aims Incidence rates of liver cancer in most populations are two to
three times higher among men than women. The higher rates among men have led to the …

Background & Aims Obesity and type 2 diabetes increase hepatocellular carcinoma (HCC)
incidence in humans and accelerate diethylnitrosamine (DEN)-induced …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. The
mechanisms for male propensity in HCC incidence, prognosis and treatment responses are …

There are significant gender differences in the incidence and mortality of hepatocellular
carcinoma (HCC). Compared with men, the incidence and mortality of HCC in women are …

E-type cyclins (cyclins E1 and E2) are components of the core cell cycle machinery and are
overexpressed in many human tumor types. E cyclins are thought to drive tumor cell …

Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) are specific innate lymphoid
cell subsets that are key for the detection and elimination of pathogens and cancer cells. In …

Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical
development. Therefore, identifying the best preclinical models can help dissect molecular …