Retinoic acid (RA) signaling is crucial for spermatogonial differentiation, which is a key step
for spermatogenesis. We explored the mechanisms underlying spermatogonial …

Aurora A kinase (AURKA) is an important regulator of cell division and is required for
assembly of the mitotic spindle. We recently reported the unusual finding that this mitotic …

The continuous regeneration of spermatogonial stem cells (SSCs) underpins
spermatogenesis and lifelong male fertility, but the developmental origins of the SSC pool …

Retinoic acid receptor α (RARA), a retinoic acid–dependent transcription factor, is expressed
in both somatic and germ cells of the testis. Rara-null male mice with global Rara mutations …

Spermatogonial stem cells (SSCs) sustain spermatogenesis and fertility throughout adult
male life. The conserved RNA-binding protein NANOS2 is essential for the maintenance of …

In mammals, spermatogonial stem cells (SSCs) arise from a subpopulation of
prospermatogonia during neonatal testis development. Currently, molecular mechanisms …

The first round, or wave, of spermatogenesis is the postnatal process of male
gametogenesis that begins with the differentiation of the first subset of spermatogonia and …

Mammalian spermatogenesis is a complex and highly ordered process by which male germ
cells proceed through a series of differentiation steps to produce haploid flagellated …

Mammalian male germ cell development takes place in the testis under the influence of a
variety of somatic cells and an incompletely defined paracrine and endocrine influences …

Meiosis is a unique type of cell division that is performed only by germ cells to form haploid
gametes. The switch from mitosis to meiosis exhibits a distinct sex-specific difference in …