Spermatogonia differentiation and meiotic initiation are complex processes essential for
male fertility. Despite knowing for nearly 60 years that retinoic acid (RA) is instrumental for …

The three major exogenous signaling systems that regulate spermatogenesis are follicle
stimulating hormone, testosterone, and retinoic acid. In mice the absence of follicle …

Throughout sexual maturation, dynamic changes in testicular macro-and microstructure and
reproductive hormone levels occur. Future adult reproductive capability is critically …

Compelling evidence from human populations worldwide suggest that sperm counts have
declined by~ 50% over the last 40 years. It is thought perinatal exposure to endocrine …

all-trans-retinoic acid (atRA), the active metabolite of vitamin A, is a ligand for several
nuclear receptors and acts as a critical regulator of many physiological processes. The …

Spermatogenesis in the mammalian testis results in the daily production of millions of
spermatozoa. This developmental process is founded upon the actions of a small population …

The developmental origins of most adult stem cells are poorly understood. Here, we report
the identification of a transcription factor—RHOX10—that is critical for the initial …

Although a raft of research has investigated spermatogonial stem cells (SSCs), and our
understanding of their roles in reproductive processes has flourished over the past several …

The onset of spermatogenesis is a tightly controlled process that takes place within the
seminiferous tubules of the neonatal mouse testis. Retinoic acid (RA), the active metabolite …

Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis,
and they provide the foundation for spermatogenesis and life-long fertility. Currently, the …