In the last decade, clear evidence has emerged that the cellular components of skeletal
muscle are important sites for the release of proteins and peptides called “myokines” …

Myostatin is a negative regulator of skeletal muscle growth secreted by skeletal myocytes. In
the past years, myostatin inhibition sparked interest among the scientific community for its …

Background Skeletal muscle atrophy is a severe condition that involves loss of muscle mass
and quality. Drug intake can also cause muscle atrophy. Biguanide metformin is the first‐line …

Myostatin (GDF-8) was discovered 25 years ago as a new transforming growth factor-β
family member that acts as a master regulator of skeletal muscle mass. Myostatin is made by …

Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

Abstract Growth differentiation factor 11 (GDF11) and myostatin (MSTN) are closely related
TGFβ family members that are often believed to serve similar functions due to their high …

Neurogenic atrophy refers to the loss of muscle mass and function that results directly from
injury or disease of the peripheral nervous system. Individuals with neurogenic atrophy may …

Skeletal muscle is under inhibitory homeostatic regulation by multiple ligands of the
transforming growth factor-β (TGFβ) superfamily. Follistatin is a secreted protein that …

In the past 20 years, myostatin, a negative regulator of muscle mass, has attracted attention
as a potential therapeutic target in muscular dystrophies and other conditions. Preclinical …

Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy.
Myostatin induces the degradation of myofibrillar proteins, such as myosin heavy chain or …