Chronic stress-induced depression is a common hallmark of many psychiatric disorders with
high morbidity rate. Stress-induced dysregulation of noradrenergic system has been …

Abstract α 1-Adrenergic receptors (α 1-ARs) are important players in peripheral and central
nervous system (CNS) regulation and function and in mediating various behavioral …

The human anterior cingulate and frontoinsular cortices are distinguished by 2 unique Layer
5 neuronal morphotypes, the von Economo neurons (VENs) and fork cells, whose biological …

The aim of the present study was to examine the effect of the brain noradrenergic system on
the expression of cytochrome P450 in the liver. The experiment was carried out on male …

Exposure to adversity during early life is a risk factor for the development of different mood
and psychiatric disorders, including depressive-like behaviors. Here, neonatal mice were …

Currently utilized antidepressants have limited effectiveness and frequently incur undesired
effects. Most antidepressants are thought to act via the inhibition of monoamine reuptake; …

Major depressive disorder (MDD) is highly comorbid with anxiety disorders. It has been
reported that the bed nucleus of the stria terminalis (BNST) is important for the induction of …

Abstract N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) is a highly selective
neurotoxin for noradrenergic projections originating from the locus coeruleus (LC). The …

Background Antidepressants can modify neuronal functioning by affecting many levels of
signal transduction pathways that are involved in neuroplasticity. We investigated whether …

Chronic stress-induced depression is a common hallmark of many psychiatric disorders with
high morbidity rate. Stress-induced dysregulation of noradrenergic system has been …