Cell cycle proteins as promising targets in cancer therapy
T Otto, P Sicinski - Nature Reviews Cancer, 2017 - nature.com
Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …
Once and only once: mechanisms of centriole duplication and their deregulation in disease
EA Nigg, AJ Holland - Nature reviews Molecular cell biology, 2018 - nature.com
Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …
p21 produces a bioactive secretome that places stressed cells under immunosurveillance
I Sturmlechner, C Zhang, CC Sine, EJ van Deursen… - Science, 2021 - science.org
INTRODUCTION Complex multicellular organisms are subject to a myriad of cellular
stresses, which can be managed through cell-intrinsic adaptation and repair mechanisms …
stresses, which can be managed through cell-intrinsic adaptation and repair mechanisms …
Aneuploidy as a promoter and suppressor of malignant growth
Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …
but the connection between chromosomal errors and malignant growth has remained …
The impact of mitotic errors on cell proliferation and tumorigenesis
MS Levine, AJ Holland - Genes & development, 2018 - genesdev.cshlp.org
Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …
Aurora‐A kinase: a potent oncogene and target for cancer therapy
M Yan, C Wang, B He, M Yang, M Tong… - Medicinal research …, 2016 - Wiley Online Library
The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …
Targeting cell-cycle machinery in cancer
Abnormal activity of the core cell-cycle machinery is seen in essentially all tumor types and
represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins …
represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins …
Mammalian cell cycle cyclins
D Martínez-Alonso, M Malumbres - Seminars in cell & developmental …, 2020 - Elsevier
Proper progression throughout the cell division cycle depends on the expression level of a
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …
Satellite cells in muscular dystrophy–lost in polarity
NC Chang, FP Chevalier, MA Rudnicki - Trends in molecular medicine, 2016 - cell.com
Recent findings employing the mdx mouse model for Duchenne muscular dystrophy (DMD)
have revealed that muscle satellite stem cells play a direct role in contributing to disease …
have revealed that muscle satellite stem cells play a direct role in contributing to disease …
Plk1 overexpression induces chromosomal instability and suppresses tumor development
G de Cárcer, SV Venkateswaran, L Salgueiro… - Nature …, 2018 - nature.com
Abstract Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors,
being frequently considered as an oncogene and an attractive cancer target. However, its …
being frequently considered as an oncogene and an attractive cancer target. However, its …