Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …

Alzheimer's disease (AD) is the most common cause of dementia and there is currently no
cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence …

Increasing evidence indicates that physical activity and exercise training may delay or
prevent the onset of Alzheimer's disease (AD). However, systemic biomarkers that can …

Background The neuropathological hallmarks of Alzheimer's disease (AD) are amyloid-β
(Aβ) plaques and neurofibrillary tangles (NFTs). The amyloid cascade theory is the leading …

It is well established that ryanodine receptors (RyanRs) are overactive in Alzheimer's
disease (AD), and it has been suggested that inhibition of RyanR is potentially beneficial for …

Apolipoprotein E (ApoE) plays multiple roles in lipid transport, neuronal signaling, glucose
metabolism, mitochondrial function, and inflammation in the brain. It is also associated with …

Alzheimer's disease (AD) is an age‐related neurodegenerative disease, and the imbalance
between production and clearance of β‐amyloid (Aβ) is involved in its pathogenesis …

Autophagy is a highly evolutionary conserved process that degrades cytosolic
macromolecules or damaged organelles (eg, mitochondria), as well as intracellular …

Aging is the main risk factor for Alzheimer's disease (AD) and other neurodegenerative
pathologies, but the molecular and cellular changes underlying pathological aging of the …

Background Autophagic flux is coordinated by a network of master regulatory genes, which
centered on transcription factor EB (TFEB). The disorders of autophagic flux are closely …