[HTML][HTML] Anticancer properties and mechanism of action of the fungal nucleoside clitocine and its derivatives

C Bailly - European Journal of Medicinal Chemistry Reports, 2023 - Elsevier
Clitocine (CLT) is an atypical nitro-containing pyrimidine nucleoside bearing a ribofuranosyl
moiety attached to the exocyclic 4-amino position. It has been isolated first from the fungus …

A novel bioactive nanoparticle synthesized by conjugation of 3-chloropropyl trimethoxy silane functionalized Fe3O4 and 1-((3-(4-chlorophenyl)-1-phenyl-1H-pyrazol …

SZ Habibzadeh, A Salehzadeh, Z Moradi-Shoeili… - Molecular Biology …, 2020 - Springer
Gastric cancer is one of the common types of cancer around the world which has few
therapeutic options. Nitrogen heterocyclic derivatives such as thiazoles are used as the …

Ethyl rosmarinate protects high glucose-induced injury in human endothelial cells

YH Shen, LY Wang, BB Zhang, QM Hu, P Wang, BQ He… - Molecules, 2018 - mdpi.com
Ethyl rosmarinate (RAE) is one of the active constituents from Clinopodium chinense
(Benth.) O. Kuntze, which is used for diabetic treatment in Chinese folk medicine. In this …

Design, synthesis, and evaluation of a new series of hydrazones as small-molecule akt inhibitors for NSCLC therapy

B Erdönmez, MD Altıntop, G Akalın Çiftçi… - ACS …, 2023 - ACS Publications
In an endeavor to identify small molecules for the management of non-small-cell lung
carcinoma, 10 new hydrazone derivatives (3a–j) were synthesized. MTT test was conducted …

Thiazole moiety: A promising scaffold for anticancer drug discovery

AF Kassem, RH Althomali, MM Anwar… - Journal of Molecular …, 2024 - Elsevier
Over the past few decades, significant advancements in the discovery of anticancer
medicines have yielded various novel agents, both synthetic and natural in origin. Thiazoles …

[HTML][HTML] A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

N Bhusare, M Kumar - Oncology Research, 2024 - ncbi.nlm.nih.gov
Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms
of treatment success and patient survival. Current treatment modalities for glioblastoma …

Quinoline‐based thiazolyl‐hydrazones target cancer cells through autophagy inhibition

V Ćurčić, M Olszewski, N Maciejewska… - Archiv der …, 2024 - Wiley Online Library
Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in
medicinal chemistry. They are considered privileged structures since they constitute several …

New N-Adducts of Thiadiazole and Thiazoline with Levoglucosenone and Evaluation of Their Significant Cytotoxic (Anti-Cancer) Activity

T Poplawski, G Galita, J Sarnik, A Macieja, R Bielski… - Cancers, 2024 - mdpi.com
Simple Summary The anticancer effects reported in several heterocyclic derivatives of
thiadiazole and thiazoline prompted us to construct functionalized new carbohydrate …

Chemistry of Oxadiazole Analogues: Current Status and Applications

A Jha, A Sen, RR Malla - Russian Journal of Bioorganic Chemistry, 2021 - Springer
Oxadiazoles are heterocyclic compounds in numerous approved, and experimental drugs,
bioactive molecules, liquid crystals, diodes and in solar cell applications. It is one of the …

Design, synthesis and molecular modeling studies of thiosemicarbazide & thiazolyl-hydrazone derivatives as potential anticancer agents and topoisomerase inhibitors

S Şenkardeş, İ Bolat, H Şahinbey, S Karakuş… - Journal of Molecular …, 2024 - Elsevier
This study involved the design, synthesis and evaluation of a series of novel
thiosemicarbazide and thiazolyl-hydrazone derivatives. The synthesized compounds were …