Alterations in the circadian system are characteristic of aging on Earth. With the decline in
physiological processes due to aging, several health concerns including vision loss …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

Circadian medicine, the study of the effects of time on health and disease has seen an
uprising in recent years as a means to enhance health and performance, and optimize …

An increasingly older population is one of the major social and medical challenges we
currently face. Between 2010 and 2050, it is estimated that the proportion of adults over 65 …

The strong interest shown in the study of the causes of aging in recent decades has
uncovered many mechanisms that could contribute to the rate of aging. These include …

Aims Disturbances in the circadian rhythm are positively correlated with the processes of
aging and related neurodegenerative diseases, which are also associated with brain iron …

Sarcopenia is an age-related condition that involves a progressive decline in muscle mass
and function, leading to increased risk of falls, frailty, and mortality. Although the exact …

Background and purpose The prevalence of cerebral small vessel disease (CSVD) is
increasing due to the accelerating global aging process, resulting in a substantial burden on …

Aging encompasses a wide array of detrimental effects that compromise physiological
functions, elevate the risk of chronic diseases, and impair cognitive abilities. However, the …

Circadian clocks may mediate lifespan extension by caloric or dietary restriction (DR). We
find that the core clock transcription factor Clock is crucial for a robust longevity and …