Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut
homeostasis and their deficiency is involved in the pathogenesis of several disorders …

The human gastrointestinal (GI) tract harbors diverse microbial communities collectively
known as the gut microbiota that exert a profound impact on human health and disease. The …

Enteric bacterial pathogens pose significant threats to human health; however, the
mechanisms by which they infect the mammalian gut in the face of daunting host defenses …

Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight.
There is ongoing debate about the mechanisms that mediate metformin's effects on energy …

Inflammatory bowel disease (IBD) affects millions of individuals worldwide annually. Enteric
reactive oxygen species (ROS) play critical roles in the physiology and pathology of IBD …

The gut mucosa of human is covered by mucus, functioning as a crucial defense line for the
intestine against external stimuli and pathogens. Mucin2 (MUC2) is a subtype of secretory …

Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of
biological functions. In particular, the T cell immunoglobulin and mucin-domain containing …

Contrary to first appearances, mucus structural biology is not an oxymoron. Though mucus
hydrogels derive their characteristics largely from intrinsically disordered, heavily …

Propionate is a short-chain fatty acid that is generated upon microbiome-mediated fiber
fermentation in the intestine. By modulating immune and metabolic pathways, propionate …

Intestinal stem cells (ISCs) play an important role in maintaining intestinal homeostasis via
promoting a healthy gut barrier. Within the stem cell niche, gut microbiota linking the …