The circadian rhythm is a 24 h internal clock within the body that regulates various factors,
including sleep, body temperature, and hormone secretion. Circadian rhythm disruption is …

Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve
Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging …

Lipoproteins in cerebrospinal fluid (CSF) of the central nervous system (CNS) resemble
plasma high-density lipoproteins (HDLs), which are a compositionally and structurally …

Insulin, insulin-like growth factors (IGF) and their receptors are highly expressed in the adult
hippocampus. Thus, disturbances in the insulin-IGF signalling pathway may account for the …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by the loss of upper and lower motor neurons, which eventually may lead to …

Cholesterol levels have been repeatedly linked to Alzheimer's Disease (AD), suggesting that
high levels could be detrimental, but this effect is likely attributed to Low‐Density Lipoprotein …

Whole-genome sequencing (WGS) provides a comprehensive view of the genome, enabling
detection of coding and non-coding genetic variation, and surveying complex regions which …

This paper proposes a new hypothesis for Alzheimer's disease (AD)—the lipid invasion
model. It argues that AD results from external influx of free fatty acids (FFAs) and lipid-rich …

The transport of low-density lipoprotein (LDL) through the endothelium is a key step in the
development of atherosclerosis, but it is notorious that phenotypic differences exist between …

Introduction Alzheimer's disease (AD) and epilepsy are reciprocally related. Among sporadic
AD patients, clinical seizures occur in 10–22% and subclinical epileptiform abnormalities …