Dopamine-releasing neurons of the ventral tegmental area (VTA) have central roles in
reward-related and goal-directed behaviours. VTA dopamine-releasing neurons are …

Ventral tegmental area (VTA) neuron firing precedes behaviors elicited by reward-predictive
sensory cues and scales with the magnitude and unpredictability of received rewards. These …

Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet
imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to …

It is estimated that nearly a third of people who abuse drugs started with prescription opioid
medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in …

1. Intracellular recordings were made from 241 ventral tegmental neurones in slices of rat
midbrain. Seventy‐seven per cent of neurones were hyperpolarized by dopamine (principal …

Physiological and pharmacological studies indicate that descending projections from the
prefrontal cortex modulate dopaminergic transmission in the nucleus accumbens septi and …

Dopamine (DA) is a key transmitter in the basal ganglia, yet DA transmission does not
conform to several aspects of the classic synaptic doctrine. Axonal DA release occurs …

The prefrontal cortex (PFC) has long been known to be involved in the mediation of complex
behavioral responses. Considerable research efforts are directed towards refining the …

Midbrain dopaminergic (DA) neurons fire bursts of activity in response to sensory stimuli,
including those associated with primary reward. They are therefore conditional bursters–the …

Recently, five members of the somatostatin receptor family have been cloned. However, little
is known about their cellular and subcellular localization in the central nervous system …