The maternal immune system protects developing offspring against pathogens before birth
via transplacental transfer and after birth through secreted milk. This transferred maternal …

Prenatal maternal immunization is an effective tool to protect mothers and infants from poor
health outcomes due to infectious diseases. We provide an overview of the rationale for the …

Background SARS-CoV-2 infection during early infancy can result in severe disease. We
evaluated the durability of maternally-derived anti-SARS-CoV-2 antibodies in infants and its …

Background Maternal pertussis immunization using Tdap vaccine is recommended in many
countries to protect newborns from severe post-natal infection. Immunological changes …

A key goal of pertussis control is to protect infants too young to be vaccinated, the age group
most vulnerable to this highly contagious respiratory infection. In the last decade, maternal …

Background To reduce the risk of pertussis-related morbidity and mortality in early life, an
increasing number of countries recommend maternal pertussis vaccination. However, there …

Historically, a neutralization antibody (NAb) assay is considered critical in immunogenicity
assessment of biologic therapeutics, even with low anti-drug antibody (ADA) positive rates …

Introduction Infant upper respiratory microbiota are derived partly from the maternal
respiratory tract, and certain microbiota are associated with altered risk of infections and …

Introduction Capsular polysaccharide (CPS) serotype-specific Immunoglobulin G (IgG) in
cord blood has been proposed as a correlate of protection against invasive Group B …

Pertussis, a highly contagious respiratory infection primarily caused by the bacterium
Bordetella pertussis, remains a public health priority largely because of the persistently high …