Targeting ferroptosis in breast cancer

Z Li, L Chen, C Chen, Y Zhou, D Hu, J Yang, Y Chen… - Biomarker …, 2020 - Springer
Ferroptosis is a recently discovered distinct type of regulated cell death caused by the
accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the …

Microalgal polyunsaturated fatty acids: Hotspots and production techniques

W Chen, T Li, S Du, H Chen, Q Wang - Frontiers in Bioengineering …, 2023 - frontiersin.org
Algae play a crucial role in the earth's primary productivity by producing not only oxygen but
also a variety of high-value nutrients. One such nutrient is polyunsaturated fatty acids …

Omega-3 fatty acids and cancer cell cytotoxicity: implications for multi-targeted cancer therapy

D D'Eliseo, F Velotti - Journal of clinical medicine, 2016 - mdpi.com
Cancer is a major disease worldwide. Despite progress in cancer therapy, conventional
cytotoxic therapies lead to unsatisfactory long-term survival, mainly related to development …

Ferroptosis and EMT: key targets for combating cancer progression and therapy resistance

Y Ren, X Mao, H Xu, Q Dang, S Weng, Y Zhang… - Cellular and Molecular …, 2023 - Springer
Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial
steps in the formation of ferroptosis include the accumulation of ferrous ions (Fe2+) and lipid …

Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells

N Pizato, BC Luzete, LFMV Kiffer, LH Corrêa… - Scientific reports, 2018 - nature.com
The implication of inflammation in pathophysiology of several type of cancers has been
under intense investigation. Omega-3 fatty acids can modulate inflammation and present …

Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis

SL Pompura, A Wagner, A Kitz… - The Journal of …, 2021 - Am Soc Clin Investig
FOXP3+ Tregs rely on fatty acid β-oxidation–driven (FAO-driven) oxidative phosphorylation
(OXPHOS) for differentiation and function. Recent data demonstrate a role for Tregs in the …

ER stress and impaired autophagy flux in neuronal degeneration and brain injury

Y Yin, G Sun, E Li, K Kiselyov, D Sun - Ageing research reviews, 2017 - Elsevier
Autophagy is a highly controlled lysosome-mediated function in eukaryotic cells to eliminate
damaged or aged long-lived proteins and organelles. It is required for restoring cellular …

Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials

SF Nabavi, S Bilotto, GL Russo, IE Orhan… - Cancer and Metastasis …, 2015 - Springer
Over the past decades, extensive studies have addressed the therapeutic effects of omega-3
polyunsaturated fatty acids (omega-3 FAs) against different human diseases such as …

Role of oleic acid in immune system; mechanism of action; a review

C Carrillo Pérez, MM Cavia Camarero… - … , 2012, v. 27, n. 4 (julio …, 2012 - riubu.ubu.es
Introduction: Although n-3 polyunsaturated fatty acids have been widely described as
antiinflammatory fats, little is known about the role of oleic acid in immune system. Aim: The …

The Role of n-3 Polyunsaturated Fatty Acids in the Prevention and Treatment of Breast Cancer

J Liu, DWL Ma - nutrients, 2014 - mdpi.com
Breast cancer (BC) is the most common cancer among women worldwide. Dietary fatty
acids, especially n-3 polyunsaturated fatty acids (PUFA), are believed to play a role in …