Clinical significance of circulating tumor cell induced epithelial-mesenchymal transition in patients with metastatic colorectal cancer by single-cell RNA-sequencing

M Kozuka, F Battaglin, P Jayachandran, J Wang, H Arai… - Cancers, 2021 - mdpi.com
Simple Summary Circulating tumor cell (CTC) detection is a non-invasive and easy way to
collect and separate single cells to use as tumor biomarkers. In this article, we show the …

[HTML][HTML] The relationship between KRAS gene mutation and intestinal flora in tumor tissues of colorectal cancer patients

X Sui, Y Chen, B Liu, L Li, X Huang… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Colorectal cancer is among the most prominent malignant tumors endangering
human health, with affected populations exhibiting an increasingly younger trend. The …

Tumor location matters, next generation sequencing mutation profiling of left-sided, rectal, and right-sided colorectal tumors in 552 patients

I Ciepiela, M Szczepaniak, P Ciepiela… - Scientific Reports, 2024 - nature.com
Despite the introduction of new molecular classifications, advanced colorectal cancer (CRC)
is treated with chemotherapy supplemented with anti-EGFR and anti-VEGF targeted therapy …

Molecular profiling of patients with advanced colorectal cancer: princess margaret cancer centre experience

JW Chiu, MK Krzyzanowska, S Serra, JJ Knox… - Clinical colorectal …, 2018 - Elsevier
Background Molecular aberrations in KRAS, NRAS, BRAF, and PIK3CA have been well-
described in advanced colorectal cancer. The incidences of other mutations are less known …

Detection of mutations in the BRAF gene in patients with KIT and PDGFRA wild-type gastrointestinal stromal tumors

K Jasek, V Buzalkova, G Minarik, A Stanclova, P Szepe… - Virchows Archiv, 2017 - Springer
Gastrointestinal stromal tumors (GISTs) are characterized by mutations in exons 9, 11, 13,
and 17 of KIT or exons 12, 14, and 18 of PDGFRA gene. However, approximately 10 to 15 …

[HTML][HTML] Paired primary and metastatic tumor analysis of somatic mutations in synchronous and metachronous colorectal cancer

K Kim, JE Kim, YS Hong, SM Ahn… - … : official journal of …, 2017 - synapse.koreamed.org
Purpose Although the mutation status of KRAS is highly concordant in primary and
metastatic lesions, it has not been generalized to other major pathway genes. Materials and …

Six‐gene Assay as a new biomarker in the blood of patients with colorectal cancer: establishment and clinical validation

X Shou, Y Li, W Hu, T Ye, G Wang, F Xu… - Molecular …, 2019 - Wiley Online Library
Colorectal cancer (CRC) is the second most common cancer in men and the third most
common cancer in women. Although long‐term survival has improved over the past 30 …

[PDF][PDF] Apoptotic effects of Corchorus olitorius L. leaf extracts in colon adenocarcinoma cell lines

G Soykut, E Becer, I Calis, S Yucecan, S Vatansever - Prog. Nutr, 2018 - researchgate.net
Corchorus olitorius L. is a highly consumed plant in Cyprus and other Eastern
Mediterranean countries and known as a medicinal food in many cultures. The aim of the …

PTEN mRNA expression is less pronounced in left- than right-sided colon cancer: a retrospective observational study

H Kuramochi, A Nakamura, G Nakajima, Y Kaneko… - BMC cancer, 2016 - Springer
Background Several recent studies have reported that patients with metastatic colorectal
cancer (CRC) whose primary tumor is located in left side of the colon have more favorable …

Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD‐L1 (CD274)‐expression: possible roles of tumour micro environmental …

S Inaguma, J Lasota… - The Journal of …, 2017 - Wiley Online Library
Abstract Aberrant PD‐L1 (CD274) expression has been described in different types of
tumour and linked to tumour aggressiveness and a poor prognosis. In primary colorectal …