Cowden syndrome is characterized by several clinical features related to tumorous lesions
primarily consisting of systemic hamartomas. The mutation of a tumor suppressor gene, the …

RAS is the most common mutated gene in colorectal cancer (CRC), and its occurrence is
associated with primary and acquired resistance to anti-epidermal growth factor receptor …

The gradual elucidation of the underlying biology of colorectal cancer has provided new
insights and therapeutic options for patients with metastatic disease which are selected …

Despite the efficacy of most cancer therapies, drug resistance remains a major problem in
the clinic. The eradication of the entire tumor and the cure of the patient by chemotherapy …

Background: Anti-epidermal growth factor receptor (EGFR) therapy has been identified to
prolong the survival of metastatic colorectal cancer (mCRC) patients without RAS mutations …

Background When a patient has multiple tumors in different organs, it is very important to
identify whether the tumors are multiple cancers or metastasis from one tumor in order to …

Introduction: Colorectal liver metastasis (CRLM) is the most frequent indication for liver
resection in many centers. Recent improvements in oncology, surgery, interventional …

结直肠癌(colorectal cancer, CRC) 是我国常见的致死性肿瘤类型之一. 根据体细胞突变谱预测
抗EGFR 单抗治疗疗效已成为转移性结直肠癌(metastatic colorectal cancer, mCRC) …

Background Mutations in the RAS/RAF pathway predict resistance to anti-epidermal growth
factor receptor antibodies in colorectal cancer (CRC), and may be targets for future …

Abstract Background The Genetic And Morphologic Evaluation (GAME) score and modified
clinical score (m-CS) are two novel prognostic models that incorporate KRAS mutation …