[HTML][HTML] Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges
Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling
pathways due to the acquisition of genetic and epigenetic changes. An array of growth …
pathways due to the acquisition of genetic and epigenetic changes. An array of growth …
[HTML][HTML] A perspective on anti-EGFR therapies targeting triple-negative breast cancer
K Nakai, MC Hung, H Yamaguchi - American journal of cancer …, 2016 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC), which lacks estrogen receptor (ER), progesterone
receptor (PR), and human epidermal growth factor receptor 2 (HER2), accounts for about 15 …
receptor (PR), and human epidermal growth factor receptor 2 (HER2), accounts for about 15 …
Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression
Nanotechnology offers many benefits, and here we report an advantage of applying RNA
nanotechnology for directional control. The orientation of arrow-shaped RNA was altered to …
nanotechnology for directional control. The orientation of arrow-shaped RNA was altered to …
The identification and characterization of breast cancer CTCs competent for brain metastasis
L Zhang, LD Ridgway, MD Wetzel, J Ngo… - Science translational …, 2013 - science.org
Brain metastatic breast cancer (BMBC) is uniformly fatal and increasing in frequency.
Despite its devastating outcome, mechanisms causing BMBC remain largely unknown. The …
Despite its devastating outcome, mechanisms causing BMBC remain largely unknown. The …
[HTML][HTML] Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy
Paclitaxel is widely used in cancer treatments, but poor water-solubility and toxicity raise
serious concerns. Here we report an RNA four-way junction nanoparticle with ultra …
serious concerns. Here we report an RNA four-way junction nanoparticle with ultra …
[HTML][HTML] Utilising network pharmacology to explore the underlying mechanism of Wumei Pill in treating pancreatic neoplasms
Y Wan, L Xu, Z Liu, M Yang, X Jiang, Q Zhang… - … and alternative medicine, 2019 - Springer
Abstract Background Wumei Pill (WMP), a famous herbal formula, has been widely used to
treat digestive system diseases in clinical practice in China for centuries. We have found a …
treat digestive system diseases in clinical practice in China for centuries. We have found a …
Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up
Studies on well characterized, large populations of estrogen receptor (ER)/progesterone
receptor (PgR)/HER2-negative [triple-negative (TN)] breast cancer (BC) patients with long …
receptor (PgR)/HER2-negative [triple-negative (TN)] breast cancer (BC) patients with long …
G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer
Tumor-associated macrophages (TAMs) have been implicated in the promotion of breast
cancer growth and metastasis, and a strong infiltration by TAMs has been associated with …
cancer growth and metastasis, and a strong infiltration by TAMs has been associated with …
The biology of progesterone receptor in the normal mammary gland and in breast cancer
AE Obr, DP Edwards - Molecular and cellular endocrinology, 2012 - Elsevier
This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse
mammary gland that has been used extensively as an experimental model. Studies have led …
mammary gland that has been used extensively as an experimental model. Studies have led …
Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies
DJ Toft, VL Cryns - Molecular Endocrinology, 2011 - academic.oup.com
The classification of breast cancer into molecular subtypes with distinctive gene expression
signatures that predict treatment response and prognosis has ushered in a new era of …
signatures that predict treatment response and prognosis has ushered in a new era of …