[HTML][HTML] Zinc: from biological functions to therapeutic potential
MI Costa, AB Sarmento-Ribeiro… - International Journal of …, 2023 - mdpi.com
The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control
intercellular communication and intracellular events that maintain normal physiological …
intercellular communication and intracellular events that maintain normal physiological …
[HTML][HTML] Zinc homeostasis in bone: Zinc transporters and bone diseases
Zinc is an essential micronutrient that plays critical roles in numerous physiological
processes, including bone homeostasis. The majority of zinc in the human body is stored in …
processes, including bone homeostasis. The majority of zinc in the human body is stored in …
Toward unzipping the ZIP metal transporters: structure, evolution, and implications on drug discovery against cancer
J Hu - The FEBS journal, 2021 - Wiley Online Library
The Zrt‐/Irt‐like protein (ZIP) family consists of divalent metal transporters, ubiquitous in all
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …
[HTML][HTML] The zinc sensing receptor, ZnR/GPR39, in health and disease
M Hershfinkel - International journal of molecular sciences, 2018 - mdpi.com
A distinct G-protein coupled receptor that senses changes in extracellular Zn2+,
ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role. Most …
ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role. Most …
How cellular Zn2+ signaling drives physiological functions
N Levaot, M Hershfinkel - Cell Calcium, 2018 - Elsevier
Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …
The effect of dietary zinc and zinc physiological status on the composition of the gut microbiome in vivo
Zinc serves critical catalytic, regulatory, and structural roles. Hosts and their resident gut
microbiota both require zinc, leading to competition, where a balance must be maintained …
microbiota both require zinc, leading to competition, where a balance must be maintained …
Emerging roles of the solute carrier family in pancreatic cancer
Z Wu, J Xu, C Liang, Q Meng, J Hua… - Clinical and …, 2021 - Wiley Online Library
Pancreatic cancer is a gastrointestinal tumor with a high mortality rate, and advances in
surgical procedures have only resulted in limited improvements in the prognosis of patients …
surgical procedures have only resulted in limited improvements in the prognosis of patients …
[HTML][HTML] Role of zinc in health and disease
LI Stiles, K Ferrao, KJ Mehta - Clinical and Experimental Medicine, 2024 - Springer
This review provides a concise overview of the cellular and clinical aspects of the role of
zinc, an essential micronutrient, in human physiology and discusses zinc-related …
zinc, an essential micronutrient, in human physiology and discusses zinc-related …
[HTML][HTML] Investigating the role of zinc in atherosclerosis: a review
T Shen, Q Zhao, Y Luo, T Wang - Biomolecules, 2022 - mdpi.com
Zinc, an indispensable micronutrient for human health, might play an important role in the
development of atherosclerosis. Zinc could be involved in the atherogenic process through …
development of atherosclerosis. Zinc could be involved in the atherogenic process through …
[HTML][HTML] The multifaceted roles of zinc in neuronal mitochondrial dysfunction
Zinc is a highly abundant cation in the brain, essential for cellular functions, including
transcription, enzymatic activity, and cell signaling. However, zinc can also trigger injurious …
transcription, enzymatic activity, and cell signaling. However, zinc can also trigger injurious …