[HTML][HTML] Zinc: from biological functions to therapeutic potential

MI Costa, AB Sarmento-Ribeiro… - International Journal of …, 2023 - mdpi.com
The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control
intercellular communication and intracellular events that maintain normal physiological …

[HTML][HTML] Zinc homeostasis in bone: Zinc transporters and bone diseases

T Huang, G Yan, M Guan - International journal of molecular sciences, 2020 - mdpi.com
Zinc is an essential micronutrient that plays critical roles in numerous physiological
processes, including bone homeostasis. The majority of zinc in the human body is stored in …

Toward unzipping the ZIP metal transporters: structure, evolution, and implications on drug discovery against cancer

J Hu - The FEBS journal, 2021 - Wiley Online Library
The Zrt‐/Irt‐like protein (ZIP) family consists of divalent metal transporters, ubiquitous in all
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …

[HTML][HTML] The zinc sensing receptor, ZnR/GPR39, in health and disease

M Hershfinkel - International journal of molecular sciences, 2018 - mdpi.com
A distinct G-protein coupled receptor that senses changes in extracellular Zn2+,
ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role. Most …

How cellular Zn2+ signaling drives physiological functions

N Levaot, M Hershfinkel - Cell Calcium, 2018 - Elsevier
Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …

The effect of dietary zinc and zinc physiological status on the composition of the gut microbiome in vivo

J Cheng, N Kolba, E Tako - Critical Reviews in Food Science and …, 2024 - Taylor & Francis
Zinc serves critical catalytic, regulatory, and structural roles. Hosts and their resident gut
microbiota both require zinc, leading to competition, where a balance must be maintained …

Emerging roles of the solute carrier family in pancreatic cancer

Z Wu, J Xu, C Liang, Q Meng, J Hua… - Clinical and …, 2021 - Wiley Online Library
Pancreatic cancer is a gastrointestinal tumor with a high mortality rate, and advances in
surgical procedures have only resulted in limited improvements in the prognosis of patients …

[HTML][HTML] Role of zinc in health and disease

LI Stiles, K Ferrao, KJ Mehta - Clinical and Experimental Medicine, 2024 - Springer
This review provides a concise overview of the cellular and clinical aspects of the role of
zinc, an essential micronutrient, in human physiology and discusses zinc-related …

[HTML][HTML] Investigating the role of zinc in atherosclerosis: a review

T Shen, Q Zhao, Y Luo, T Wang - Biomolecules, 2022 - mdpi.com
Zinc, an indispensable micronutrient for human health, might play an important role in the
development of atherosclerosis. Zinc could be involved in the atherogenic process through …

[HTML][HTML] The multifaceted roles of zinc in neuronal mitochondrial dysfunction

HY Liu, JR Gale, IJ Reynolds, JH Weiss, E Aizenman - Biomedicines, 2021 - mdpi.com
Zinc is a highly abundant cation in the brain, essential for cellular functions, including
transcription, enzymatic activity, and cell signaling. However, zinc can also trigger injurious …