Multifunctional approaches utilizing polymeric micelles to circumvent multidrug resistant tumors

SS Kesharwani, S Kaur, H Tummala… - Colloids and Surfaces B …, 2019 - Elsevier
The concerns impeding the success of chemotherapy in cancer is descending efficacy of
drugs due to the development of multiple drug resistance (MDR). The current efforts …

[HTML][HTML] Quality by design based formulation study of meloxicam-loaded polymeric micelles for intranasal administration

B Sipos, P Szabó-Révész, I Csóka, E Pallagi, DG Dobó… - Pharmaceutics, 2020 - mdpi.com
Our study aimed to develop an “ex tempore” reconstitutable, viscosity enhancer-and
preservative-free meloxicam (MEL)-loaded polymeric micelle formulation, via Quality by …

The landscape of nanoparticle-based siRNA delivery and therapeutic development

M Moazzam, M Zhang, A Hussain, X Yu, J Huang… - Molecular Therapy, 2024 - cell.com
Five small interfering RNA (siRNA)-based therapeutics have been approved by the Food
and Drug Administration (FDA), namely patisiran, givosiran, lumasiran, inclisiran, and …

Recent progress of polymeric nanogels for gene delivery

R Kandil, OM Merkel - Current opinion in colloid & interface science, 2019 - Elsevier
With its nearly unrestricted possibilities, gene therapy attracts more and more significance in
modern-day research. The only issue still seeming to hold back its clinical success is the …

Spatio-temporal control strategy of drug delivery systems based nano structures

N Rahoui, B Jiang, N Taloub, YD Huang - Journal of Controlled Release, 2017 - Elsevier
The drug instability, toxicity and the barrier to the target area necessitate a suitable drug
delivery system with an external or internal control of the release. Spatio-temporal control …

Nanoparticle formulations to enhance tumor targeting of poorly soluble polyphenols with potential anticancer properties

MC Bonferoni, S Rossi, G Sandri, F Ferrari - Seminars in Cancer Biology, 2017 - Elsevier
Polyphenols have been extensively studied for their relevant anticancer activity. Quite often
however their instability, extensive metabolization, low bioavailability and poor solubility limit …

Ketoconazole encapsulated in chitosan-gellan gum nanocomplexes exhibits prolonged antifungal activity

S Kumar, P Kaur, M Bernela, R Rani… - International journal of …, 2016 - Elsevier
The objective of the present study was to prepare ketoconazole loaded chitosan-gellan gum
(CSGG) nanoparticles and to evaluate them for antifungal activity against Aspergillus niger …

Block copolymer prodrugs: Synthesis, self‐assembly, and applications for cancer therapy

D Dutta, W Ke, L Xi, W Yin, M Zhou… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Block copolymer prodrugs (BCPs) have emerged as one of the most promising anticancer
drug delivery strategies, which can self‐assemble into nanoparticles with optimal …

Synthesis and characterization of stimuli responsive micelles from chitosan, starch, and alginate based on graft copolymers with polylactide-poly (methacrylic acid) …

A Pourjavadi, FB Kashani, M Doroudian… - International Journal of …, 2023 - Elsevier
The primary objective of this paper is to serve as a comprehensive study on the synthesis of
stimulus-sensitive micelles based on polysaccharides. In pursuit of this goal …

Soluplus® as a solubilizing excipient for poorly water-soluble drugs: recent advances in formulation strategies and pharmaceutical product features

MS Attia, A Elshahat, A Hamdy, AM Fathi… - Journal of Drug Delivery …, 2023 - Elsevier
Since the emergence of Soluplus®(SOL) as a commercial graft copolymer, several
publications have been issued on its promising potential as a solubilizing excipient that …